Public framework governance
Governance.
Stability, contradictions, revisions, and terminology drift — surfaced transparently. Trust is engineered by exposure, not by suppression.
7
Concepts tracked
1
Open contradictions
5
Deprecated terms
8
Logged revisions
Concept stability matrix
| Concept | Tier | Stability | Evidence | Last reassessed |
|---|---|---|---|---|
| host-capacity-model | Framework principle | evolving0.61 | 0.72 developing | 2026-05-11 |
| colonocyte-bioenergetics | Framework principle | foundational0.88 | 0.85 mature | 2026-04-15 |
| oxygen-gradient-failure | Framework principle | foundational0.92 | 0.80 mature | 2026-04-15 |
| dysbiosis-ecological-adaptation | Framework principle | evolving0.68 | 0.70 developing | 2026-04-20 |
| inflammatory-bioenergetics | Mechanistic hypothesis | evolving0.68 | 0.60 developing | 2026-04-15 |
| nitrate-respiration | Framework principle | foundational0.93 | 0.82 mature | 2026-04-15 |
| mitochondrial-barrier-failure | Mechanistic hypothesis | evolving0.60 | 0.55 developing | 2026-04-15 |
Recent revisions
- evidenceinflammatory-bioenergetics— Weakened by partial non-replication of immunometabolism findings in human mucosa.
- definitionmitochondrial-barrier-failure— Refined definition to reference ATP throughput rather than concentration.
- evidencehost-capacity-model— Strengthened by replication of butyrate-driven O2 consumption study.
- scopehost-capacity-model— Explicit non-scope: structural lesions and primary IEMs.
- scopeinflammatory-bioenergetics— Restricted scope to mucosal immunometabolism; excluded systemic generalization.
- terminologymitochondrial-barrier-failure— Deprecated 'mitochondrial leaky gut' framing.
- deprecationoxygen-gradient-failure— Deprecated 'oxygen collapse' and 'gut oxygen leak syndrome' phrasings.
- terminologyhost-capacity-model— Deprecated 'host capacity theory' in favor of 'Host Capacity Model'.
Terminology drift
- oxygen collapse → oxygen-gradient failureAmbiguous; conflates gradient loss with absolute O2 changes.
- gut oxygen leak syndrome → oxygen-gradient failurePseudo-clinical framing implying a discrete disease entity.
- host capacity theory → Host Capacity Model'Theory' overstates current evidence maturity.
- dysbiosis is normal → dysbiosis as ecological adaptationMisrepresents the ecological-adaptation framing.
- mitochondrial leaky gut → mitochondrial barrier failureCompresses two distinct mechanisms into a slogan.
Tracked contradictions
- Dysbiosis-first vs Host-first causationstructural · unresolved
The dominant clinical narrative places dysbiosis upstream; HCM places host bioenergetics upstream. Both frames have partial empirical support and partial explanatory failure.
- Junctional vs bioenergetic primacy in barrier failuremoderate · monitoring
Junctional-protein-centric models frame barrier failure as a primary structural lesion; the bioenergetic frame treats it as downstream of ATP capacity.