- Host Capacity Model·April 12, 2025· 14 min
The Host Capacity Model: an introduction
Why colonocyte bioenergetic failure — not microbial overgrowth — is the upstream lesion driving chronic gut dysfunction.
#HCM#colonocyte#framework - Mitochondria·March 21, 2025· 11 min
The CD38–NAD⁺–SIRT3 cascade in chronic illness
Chronic low-grade inflammation drives CD38 expression, depletes mitochondrial NAD⁺, and disables SIRT3-dependent acetylation control of the matrix proteome.
#NAD#CD38#SIRT3#mitochondria - MCAS & Mast Cells·February 14, 2025· 9 min
Stratifying MCAS: not all activation patterns are the same
A practical mechanistic stratification of mast cell activation patterns, with implications for which interventions actually move the needle.
#MCAS#mast cells#stratification - Fertility·January 30, 2025· 12 min
The 90-day oocyte mitochondrial protocol
The folliculogenesis window is roughly 90 days. The interventions that actually shift oocyte mitochondrial competence operate on that timescale.
#fertility#oocyte#mitochondria - SIBO·December 10, 2024· 8 min
H₂S Complex IV poisoning in recurrent SIBO
Sulfide-producing taxa can chemically inhibit Complex IV at the colonocyte mitochondrion. This is one of several upstream reasons SIBO recurs after antimicrobial treatment.
#SIBO#H2S#complex IV - Case Reasoning·November 2, 2024· 16 min
Case reasoning: a long-haul presentation with overlapping syndromes
Walking through the mechanistic re-read of a six-year case with overlapping POTS, MCAS, and post-infectious gut dysfunction.
#case#long covid#POTS
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