Mechanistic case analysis for complex chronic illness
BiomeLogic reconstructs complex cases across intestinal bioenergetics, microbial ecology, barrier function, immune signaling, autonomic regulation, and mitochondrial capacity—then turns the reasoning into a structured report for discussion with your licensed care team.
Designed for recurrent SIBO, MCAS-like presentations, post-viral illness, dysautonomia, expanding food reactions, and cases that remain fragmented across multiple specialists.
Explore the Host Capacity Model →
Educational systems-biology consulting. Not diagnosis, treatment, or medical care.
Case synthesis
schematic01 · Fragmented inputs
02 · Reconstruction layers
03 · Structured output
Delivered as a written mechanistic report
When the case no longer fits one specialty
BiomeLogic is designed for cases in which gastrointestinal, immune, autonomic, metabolic, and post-viral findings may be interacting—but have repeatedly been evaluated as separate problems.
What you actually receive
Symptoms, chronology, laboratories, imaging, prior interventions, medications, supplements, contradictions, and unresolved findings are reviewed as one system.
The analysis distinguishes leading mechanisms from alternative explanations, missing evidence, and findings that do not fit.
A 60–90 minute session tests the proposed model against the details that may not appear in the records.
You receive a structured mechanistic analysis designed to be shared and discussed with your licensed care team.
The framework
Many approaches begin with microbial composition: identify the organisms, reduce them, and expect the intestinal environment to recover. In recurrent cases, that sequence may be incomplete.
The Host Capacity Model examines whether impaired epithelial fuel use, mitochondrial capacity, oxygen-gradient regulation, barrier integrity, immune signaling, or motility has changed the habitat in which the microbiome operates.
This is evaluated as a candidate explanatory framework—not assumed to be the cause of every case. The analysis must account for competing mechanisms and findings that the model cannot explain.
Inspect the work before you commit
BiomeLogic publishes its analytical structure openly so prospective clients and clinicians can examine the quality, limits, and transparency of the work.
The structure of the written deliverable: causal hypotheses, evidence tiers, competing explanations, contradictions, and questions for clinician discussion.
View the sample reportA long-form reconstruction of a complex case, including what the Host Capacity Model explained and what it did not.
Read the worked caseReview the framework audit, counterarguments, and claim ledger used to separate established physiology from mechanistic inference.
Review the evidence architectureBiomeLogic does not publish anonymous or illustrative testimonials. Verified client statements, when clients choose to leave them, appear on the testimonials page.
Selected research
SIBO
Recurrent SIBO may represent an equilibrium state of an unaddressed host substrate failure. Antimicrobials reduce overgrowth without restoring the colonocyte bioenergetic capacity that defines which microbes can dominate. A Host Capacity Model reading of the recurrence cycle, the SLC5A8 / Fe-S / CD38-NAD+-SIRT3 mechanisms behind it, and what an HCM-anchored approach actually looks like.
MCAS & Mast Cells
Treatment-resistant MCAS may, in a subset of people, be a stratification problem rather than a stabilization problem. At least four candidate mechanistic patterns can contribute to the MCAS phenotype — barrier-driven, neuroimmune/vagal, chemical/toxicant, and clonal/KIT-driven — and they require different upstream interventions. A Host Capacity Model reading of why cromolyn, ketotifen, and the standard stack fail, and what stratification-anchored care looks like.
Host Capacity Model
What three years of research actually shows about viral persistence, serotonin depletion, mitochondrial impairment, microclots, and EBV reactivation — and a candidate upstream layer that may tie them together.
Scope and clinician compatibility
BiomeLogic provides educational systems-biology analysis. It does not diagnose, prescribe, treat, triage, or replace licensed medical care. Major claims are separated by evidence level, and written analyses are designed for discussion with the client's licensed medical team.
Based in Bowie, Maryland, United States, working remotely worldwide. Maryland & DMV consulting →
Start with fit—not payment
Gate 1 is a free, five-minute written fit screen. No files, laboratory reports, or payment are required. You will receive a written response within two business days.
No medical advice is provided during the fit screen or discovery call.