Chronic conditions addressed through the Host Capacity Model
The conditions on this page travel together because they share an upstream mechanism. Each pillar reframes the dominant search intent through the same framework — the host substrate that selects for the pattern, not the pattern itself.
- SIBO
SIBO that keeps coming back
Recurrent SIBO reframed as colonocyte bioenergetic failure rather than a primary microbial disease.
Read the SIBO pillar → - MCAS
MCAS that doesn't respond to standard treatment
Four mechanistically distinct MCAS patterns and why stabilizers fail when the upstream driver is missed.
Read the MCAS pillar → - Long COVID
Long COVID and post-viral chronic illness
Post-viral gut–immune patterns: persistent CD38 activation, NAD+ depletion, and barrier failure.
Read the Long COVID pillar → - Dysbiosis
Chronic gut dysbiosis
Why dysbiosis recurs after antibiotics, probiotics, and protocols — and what the substrate environment actually requires.
Read the Dysbiosis pillar → - hEDS–POTS–MCAS
The hEDS–POTS–MCAS triad
Why hypermobility, dysautonomia, and mast cell activation travel together — the shared connective-tissue and bioenergetic substrate.
Read the hEDS–POTS–MCAS pillar → - Mitochondrial dysfunction
Mitochondrial-pattern chronic fatigue
Complex IV insufficiency, iron–sulfur cluster failure, and CD38-driven NAD+ collapse in chronic fatigue presentations.
Read the Mitochondrial dysfunction pillar →
One framework, six clinical readouts
These are not six separate diseases that happen to share a clinician. They are six distinct readouts of the same underlying problem: a host that has lost the bioenergetic capacity to maintain its own substrate environment. The microbiome, the mast cell network, the autonomic system, and the connective tissue scaffolding all depend on that capacity. When it fails, each system fails in its own characteristic way — and the patient ends up with a stack of diagnoses that nobody can explain in one sentence.
The Host Capacity Model is that one sentence. The condition pillars above are what it looks like in practice. Read the one that matches your case first. When you finish, the cross-conditional links at the bottom of each pillar will take you to the next pattern that is almost certainly running alongside it.
Not sure which pattern is dominant in your case?
The Host Capacity Score is a 4-minute assessment that ranks which axis — energy, microbiome, mitochondria, mast cells, or barrier — is most likely driving your presentation.