Flagship Frameworks.
Definitive, citation-grade pages for the load-bearing concepts of the Host Capacity Model.
The Host Capacity Model
Recurrent gut dysfunction reflects failing host bioenergetic capacity, not a primary microbial disease.
Colonocyte Bioenergetics and Gut Stability
Colonocyte mitochondria sustain the oxygen sink that holds the colonic ecosystem in its anaerobic steady state.
Oxygen-Gradient Failure
Loss of the epithelial-to-lumen oxygen gradient is the pivotal hinge between host capacity loss and dysbiosis.
Dysbiosis as Ecological Adaptation
Dysbiosis is not primary pathology but the community's adaptive response to a degraded host habitat.
Inflammatory Bioenergetics
Mucosal inflammation rewires host and microbial energy economics, amplifying habitat collapse.
Nitrate Respiration and Chronic Gut Dysfunction
Host-derived nitrate fuels facultative anaerobe respiration, sustaining chronic dysbiosis in inflamed gut habitats.
Mitochondrial Barrier Failure
Tight-junction failure is downstream of epithelial mitochondrial insufficiency, not a primary lesion.