Topical Hubs
Authoritative deep-dive hubs on the core mechanistic clusters of systems-biology consulting.
Colonocyte Bioenergetics — Where to Start
An ordered reading path through butyrate oxidation, the oxygen gradient and NAD+ collapse — why gut protocols stop working. Educational review.
Post-COVID Mast Cell Activation: Who Is Vulnerable and Why
Why some people develop mast cell activation after COVID and others do not: HαT, MTHFR, AOC1 and ACE2 variants, NAD+ loss and progenitor reprogramming.
SIBO Mechanisms & Diagnostic Limits
Why SIBO breath tests mislead, what migrating motor complex failure means, and how host energy collapse — not the bacteria — drives recurrent overgrowth.
The Gut–Fertility Axis
How dysbiosis impairs follicular aromatase, suppresses local estrogen synthesis, and degrades egg quality independent of systemic hormone levels.
Mast Cell Activation — Where to Start
An ordered reading path through mast cell activation: why tryptase can be normal, why antihistamines plateau, and what sits upstream of the mast cell.
Long COVID — Gut, Dysautonomia and POTS
An ordered reading path through post-viral gut dysfunction, POTS and dysautonomia: what persists after the infection clears, and why it persists.