Topical Hubs
Authoritative deep-dive hubs on the core mechanistic clusters of systems-biology consulting.
Colonocyte Bioenergetics
How mitochondrial energy failure in the colonocyte drives dysbiosis, leaky gut, SIBO, and treatment resistance. The Host Capacity Model explained.
Post-COVID Mast Cell Activation Syndrome (MCAS)
Why some people develop chronic MCAS after COVID and others do not. Genetics (HαT, MTHFR, AOC1, ACE2), epigenetic stem cell reprogramming, and the spike-ACE2 mast cell axis.
SIBO Mechanisms & Diagnostic Limits
Why SIBO breath tests are unreliable, what migrating motor complex failure actually means, and how host energy collapse — not the bacteria — drives recurrent overgrowth.
The Gut–Fertility Axis
How dysbiosis impairs follicular aromatase, suppresses local estrogen synthesis, and degrades egg quality independent of systemic hormone levels.