The Host Capacity Model — clinician brief
A candidate upstream-mechanism framework for recurrent SIBO, MCAS-spectrum presentations, post-viral gut–immune dysfunction, and hEDS/POTS overlap. This page is a printable summary suitable for clinic distribution. It does not replace clinical judgment.
Core claim
Colonocyte bioenergetic failure (driven primarily by NAD⁺ depletion under sustained inflammatory drive and by loss of luminal butyrate availability) raises luminal pO₂, collapses physiological hypoxia, and shifts microbial selection toward facultative anaerobes. The system has two stable equilibria; recurrent symptoms reflect the collapsed attractor, not a single pathogen.
Where the model fits
- Recurrent SIBO after appropriate antimicrobial courses
- MCAS-pattern presentations with gut triggers
- Post-viral / Long-COVID gut–immune patterns
- hEDS / POTS overlap with mast-cell symptoms
- Patients with "normal labs, persistent symptoms"
Where the model may not apply
- Active IBD requiring gastroenterology management
- Structural disease, malignancy, or undiagnosed bleeding
- Acute infectious enteritis
- Primary immunodeficiency
- Pediatric cases without specialist co-management
What a referral looks like
BiomeLogic provides independent systems-biology consultation and mechanistic case analysis. It is not medical care and does not replace the referring clinician. Deliverables include a written case analysis, a candidate mechanism map, and lab-interpretation notes — all framed as hypotheses for the treating clinician to weigh.
Scope of practice
Educational and consultative only. Not diagnosis. Not treatment. Not a prescription. The author is not a licensed clinician.