The Host Capacity Model — clinician brief
A hypothesis-generating framework used to organise complex, multisystem histories — recurrent SIBO, MCAS-spectrum presentations, post-viral gut–immune patterns, and hEDS/POTS overlap. It has not undergone formal external peer review. This page is a printable summary; it does not replace clinical judgment.
Core hypothesis
The model proposes that impaired colonocyte bioenergetics may raise luminal oxygen availability, reduce the physiological hypoxia of the healthy colon, and shift microbial selection toward facultative anaerobes. Reduced luminal butyrate availability and sustained inflammatory drive are treated as candidate contributors rather than demonstrated causes. On this reading, recurrent symptoms may reflect a self-maintaining host state rather than a single persistent pathogen. Whether a given case fits this pattern is an open question to be tested, not an assumption.
Evidence standing: the oxygen–facultative-anaerobe relationship rests on established biology in animal models; its extension to recurrent SIBO, MCAS, and post-viral presentations in humans is mechanistic inference with meaningful residual uncertainty. Claim-by-claim grading is published at biomelogic.net/framework-audit.
Where the model may be informative
- Recurrent SIBO after appropriate antimicrobial courses
- MCAS-pattern presentations with gut triggers
- Post-viral / Long-COVID gut–immune patterns
- hEDS / POTS overlap with mast-cell symptoms
- Long histories with fragmented findings across several reports
Where clinician-led evaluation comes first
- Active IBD requiring gastroenterology management
- Structural disease, malignancy, or undiagnosed bleeding
- Acute infectious enteritis
- Primary immunodeficiency
- Pediatric cases without specialist co-management
What a referral produces
A written educational synthesis: a reconstructed timeline, candidate mechanisms with the evidence supporting and contradicting each, alternative explanations, missing information, explicit uncertainty, and questions for discussion with the treating clinician. Referral does not create a treatment relationship with BiomeLogic, requires no endorsement from the referring clinician, and involves no referral fee, commission, or reciprocal arrangement.
Scope
BiomeLogic produces independent educational analysis. It does not diagnose, prescribe, direct treatment, or replace evaluation by licensed healthcare professionals. The author is not a licensed clinician.