Clinical-pattern inference
Chronic dysbiosis may persist when host epithelial bioenergetic capacity remains impaired, regardless of antimicrobial intervention.
Evidence summary
Inferred from documented high relapse rates after antibiotic therapy for IBS-SIBO and from mechanistic work on host bioenergetics.
Representative citations
Limitations
No controlled human trial directly tests bioenergetic restoration as a primary intervention for recurrent SIBO.
Competing explanation
Relapse may be driven by motility, structural, or dietary factors independent of host bioenergetics.
What would weaken this claim
A trial showing durable resolution of recurrent SIBO via antimicrobial-only strategies in cases with documented bioenergetic impairment.
Related pages
Educational mechanistic analysis only. Not medical diagnosis or treatment.