Hypothesis
Excess hydrogen sulfide may simultaneously contribute to SIBO-pattern symptoms and mast cell activation through colonocyte energy failure.
Evidence summary
Built on established H₂S inhibition of cytochrome c oxidase plus pattern observation in clinical cases.
Representative citations
Limitations
Direct measurement of mucosal H₂S in MCAS patients is not routine.
Competing explanation
MCAS in many cases is genetically driven (KIT mutations) or independent of microbial H₂S.
What would weaken this claim
Trials showing no MCAS improvement when mucosal H₂S burden is reduced.
Related pages
Educational mechanistic analysis only. Not medical diagnosis or treatment.