- Frameworks·June 1, 2026· 23 min·HCM interpretationEducational only
What Actually Causes PCOS? A Mechanistic Reading of Polycystic Ovary Syndrome
PCOS is not primarily ovarian. Gut dysbiosis, insulin resistance, estrobolome dysfunction, mitochondrial failure, and the CD38-NAD+-SIRT3 cascade drive the disease. Birth control and metformin contain the readout while the upstream lesions persist.
#pcos#polycystic-ovary-syndrome#insulin-resistance#gut-dysbiosis#dogma-hypothesis#host-capacity-model#metformin#berberine#inositol#lean-pcos#hashimotos#estrobolome#womens-health#fertility#hyperandrogenismRead mechanism → - Fertility·May 30, 2026· 21 min·Mechanistic inferenceEducational only
Why Does Endometriosis Come Back After Surgery? The Gut, Estrobolome, and Bioenergetic Mechanism
Endometriosis recurs because excision removes lesions but not the substrate that selected for them. A mechanistic reading of the gut estrobolome, beta-glucuronidase-driven estrogen recirculation, LPS-driven inflammation, pelvic mast cell infiltration, mitochondrial dysfunction, and iron-driven oxidative damage — and why surgery and hormonal suppression contain the disease but rarely resolve it.
#endometriosis#endometriosis-recurrence#estrobolome#beta-glucuronidase#gut-microbiome#host-capacity-model#sibo#mcas#lps#mast-cells#mitochondrial-dysfunction#perimenopause#womens-health#hormonal-healthRead mechanism →
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