The limits are published alongside the reasoning.
- Evidence tiers
Every article carries an explicit evidence tier, so established biology is never presented as if it were clinical proof.
Read the claim ledger - What this does not prove
Mechanistic pieces are required to state their own limits and the competing explanations that would fit the same data.
See the counterarguments - Published corrections
Where the reasoning has been revised, the revision is recorded rather than quietly edited away.
Review the standards
Pick the sentence that sounds like your situation.
- Why does my SIBO keep coming back?
- Are SIBO breath tests actually reliable?
- Why don't antihistamines settle my symptoms?
- Can I have mast cell activation with normal tryptase?
- Why won't my Long COVID symptoms resolve?
- Why did COVID trigger this in me and not others?
- Why are my labs normal when I feel terrible?
- Why doesn't my stool test match my symptoms?
- Why does every protocol stop working after two weeks?
- Why did butyrate or probiotics make me worse?
- What do bile acids have to do with my gut symptoms?
- Can gut health affect my hormones and egg quality?
Educational mechanistic writing. It does not diagnose, and it does not replace the clinician treating you.
Seven mechanistic threads run through this library.
Recurrent SIBO & breath-test interpretation
14 articles · recurrent SIBO
Mast-cell activation, tryptase & histamine
19 articles · mast cell activation
Long COVID, post-viral gut–immune & POTS
13 articles · Long COVID gut symptoms
Colonocyte bioenergetics, butyrate & oxygen
19 articles · colonocyte bioenergetics
Bile acids, TUDCA & C. difficile ecology
5 articles · bile acid dysfunction
Gut–hormone axis, fertility & estrobolome
3 articles · gut microbiome and fertility
Lab-pattern interpretation
6 articles · lab pattern interpretation
3 articles
- Case Reasoning· July 29, 2026· 32 min· Clinical pattern observation
What a Two-Decade Steroid-Dependent IBD Case Revealed About Redox Collapse, Malabsorption, Microbial Instability, and Host Capacity
A man in his forties with two decades of steroid-dependent inflammatory bowel disease was taking four grams of vitamin C daily — and his ascorbate marker sat near the bottom of the range. That contradiction opened a full mechanistic case analysis of redox collapse, fat malabsorption, microbial instability, and host capacity.
#case-study#ibd#crohns - Frameworks· May 29, 2026· 21 min· HCM interpretation
What May Be Driving IBD? A Mechanistic Reading of Crohn's Disease and Ulcerative Colitis
IBD is not a single autoimmune disease. At the cellular level both Crohn's and ulcerative colitis are dominated by colonocyte bioenergetic failure — loss of butyrate oxidation, collapse of the gut oxygen gradient, and the inflammatory cascade that follows. A mechanistic reading anchored in primary research from Roediger 1990 onward, and why standard immunosuppression contains the response but does not restore the upstream lesion.
#ibd#crohns-disease#ulcerative-colitis - Mitochondria· May 25, 2026· 5 min· Mechanistic inference
Ulcerative Colitis Starts in the Mitochondrion
For forty years the field treated UC as immune dysregulation. The 2024 and 2025 literature finally admits what was upstream all along.
#ulcerative-colitis#ibd#mitochondria
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