- Frameworks·July 30, 2026· 11 min·HCM interpretationEducational only
SIBO, MCAS, POTS and Food Intolerance May Be One Self-Sustaining System
For years, SIBO, MCAS, POTS, dysautonomia, food intolerance, chronic fatigue, neurological symptoms, and mitochondrial dysfunction have been treated as separate diagnoses.
#sibo#mcas#pots#food-intolerance#histamine#autonomic-dysfunction#mast-cells#host-capacity-model#systems-biology#feedback-loopsRead mechanism → - MCAS & Mast Cells·June 9, 2026· 13 min·Mechanistic inferenceEducational only
Why Mast Cell Activation May Be the Last Domino, Not the First — A Systems-Biology Reframe of MCAS
For decades, the mast cell has carried a reputation it may not fully deserve. We learned it as the cell of allergy: the histamine grenade, the hive, the wheeze, the anaphylactic emergency. In that framing, Mast Cell Activation Syndrome (MCAS) becomes a straightforward story —…
#mcas#mast-cells#systems-biology#histamine#barrier-failure#dysbiosis#host-capacity-model#immune-thresholdRead mechanism →
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