- Host Capacity Model·June 11, 2026· 28 min·Mechanistic inferenceEducational only
Why Dysbiosis, SIBO, Hydrogen Sulfide Intolerance, MCAS, and Long COVID May All Be Downstream of a Single Event
Dysbiosis, SIBO, hydrogen sulfide intolerance, MCAS, and long COVID may all be downstream of one event: the colonocyte losing control of oxygen, butyrate, and its own mitochondria. The Host Capacity Model in full.
#host-capacity-model#colonocyte#butyrate#mitochondria#dysbiosis#sibo#hydrogen-sulfide#mcas#long-covid#peroxynitrite#iron-sulfur-clusters#nad#cd38#glutathione#slc5a8#oxia-dysbiosis-loop#ppar-gamma#hif#cardiolipin#ferroptosisRead mechanism → - Frameworks·May 29, 2026· 21 min·HCM interpretationEducational only
What Actually Causes IBD? A Mechanistic Reading of Crohn's Disease and Ulcerative Colitis
IBD is not a single autoimmune disease. At the cellular level both Crohn's and ulcerative colitis are dominated by colonocyte bioenergetic failure — loss of butyrate oxidation, collapse of the gut oxygen gradient, and the inflammatory cascade that follows. A mechanistic reading anchored in primary research from Roediger 1990 onward, and why standard immunosuppression contains the response but does not restore the upstream lesion.
#ibd#crohns-disease#ulcerative-colitis#inflammatory-bowel-disease#biologics#colonocyte-bioenergetics#host-capacity-model#butyrate#slc5a8#faecalibacterium-prausnitzii#akkermansia#mitochondrial-dysfunction#cd38#nadRead mechanism → - SIBO·May 25, 2026· 16 min·Mechanistic inferenceEducational only
Why Does SIBO Keep Coming Back After Treatment?
Recurrent SIBO is the equilibrium state of an unaddressed host substrate failure. Antimicrobials reduce overgrowth without restoring the colonocyte bioenergetic capacity that defines which microbes can dominate. A Host Capacity Model reading of the recurrence cycle, the SLC5A8 / Fe-S / CD38-NAD+-SIRT3 mechanisms behind it, and what an HCM-anchored approach actually looks like.
#sibo#recurrent-sibo#host-capacity-model#dysbiosis#h2s-sibo#methane-sibo#rifaximin#case-reasoning#mechanism#colonocyte-bioenergetics#nad#sirt3#cd38#slc5a8Read mechanism →
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