19 articles · showing 12
- Case Reasoning· August 3, 2026· 12 min· Clinical pattern observation
The Microbial Metabolites That May Be Rewiring the Brain: The Hidden Link Between SIBO, IBS, MCAS, Autism, ADHD, Glutamate, and Catecholamine Dysfunction
HPHPA, hydrogen sulfide, D-lactate and ammonia are microbial metabolites that may pressure catecholamine regulation through dopamine β-hydroxylase, COMT and mitochondrial ATP. A case-anchored look at the hidden link between SIBO, IBS, MCAS, POTS, ADHD-like symptoms and autism-spectrum features — a metabolite-driven mechanism rather than a purely compositional dysbiosis.
#hphpa#clostridia#dopamine-beta-hydroxylase - SIBO· August 2, 2026· 13 min· Mechanistic inference
Beyond Bacteria: Is Bile Acid Ecology One of the Missing Pieces in Chronic SIBO?
Over the last several years, I have spent countless hours studying chronic gut dysfunction while working with individuals suffering from small intestinal bacterial overgrowth (SIBO), hydrogen sulfide overgrowth, mast cell activation syndrome (MCAS)-related gastrointestinal sym…
#bile-acids#sibo#bile-acid-malabsorption - Frameworks· July 30, 2026· 11 min· HCM interpretation
SIBO, MCAS, POTS and Food Intolerance May Be One Self-Sustaining System
For years, SIBO, MCAS, POTS, dysautonomia, food intolerance, chronic fatigue, neurological symptoms, and mitochondrial dysfunction have been treated as separate diagnoses.
#sibo#mcas#pots - Host Capacity Model· June 11, 2026· 28 min· Mechanistic inference
Why Dysbiosis, SIBO, Hydrogen Sulfide Intolerance, MCAS, and Long COVID May All Be Downstream of a Single Event
Dysbiosis, SIBO, hydrogen sulfide intolerance, MCAS, and long COVID may all be downstream of one event: the colonocyte losing control of oxygen, butyrate, and its own mitochondria. The Host Capacity Model in full.
#host-capacity-model#colonocyte#butyrate - SIBO· June 1, 2026· 22 min· Mechanistic inference
What May Be Driving GERD and Acid Reflux? Why Long-Term PPI Use Often Makes It Worse
GERD is rarely too much acid. It's lower esophageal sphincter dysfunction with pressure from SIBO, gastroparesis, vagal compromise, and bioenergetic failure. Long-term PPI use often perpetuates the underlying disease through rebound hypersecretion and SIBO induction.
#gerd#acid-reflux#ppi - Frameworks· June 1, 2026· 22 min· HCM interpretation
What May Be Driving Fibromyalgia? The Mitochondrial, Mast Cell, and Small Fiber Neuropathy Mechanisms Standard Treatment Misses
Fibromyalgia has four upstream drivers: mitochondrial dysfunction, mast cell activation, small fiber neuropathy, and gut-brain axis dysfunction. Lyrica and Cymbalta act on central amplification, not on the peripheral lesions producing the input — which is why response is so often partial.
#fibromyalgia#chronic-pain#mitochondrial-dysfunction - Frameworks· May 31, 2026· 22 min· HCM interpretation
What May Be Driving Chronic Migraine? A Mechanistic Reading of Treatment-Resistant Migraine
Chronic migraine has four upstream drivers: mitochondrial bioenergetic failure, dural mast cell activation, gut-brain axis dysfunction, and hormonal-vasomotor instability. Most treatment-resistant cases (including CGRP antibody non-responders) need the dominant driver addressed at its upstream point.
#chronic-migraine#migraine#cgrp - Fertility· May 30, 2026· 21 min· Mechanistic inference
Why Does Endometriosis Come Back After Surgery? The Gut, Estrobolome, and Bioenergetic Mechanism
Endometriosis recurs because excision removes lesions but not the substrate that selected for them. A mechanistic reading of the gut estrobolome, beta-glucuronidase-driven estrogen recirculation, LPS-driven inflammation, pelvic mast cell infiltration, mitochondrial dysfunction, and iron-driven oxidative damage — and why surgery and hormonal suppression contain the disease but rarely resolve it.
#endometriosis#endometriosis-recurrence#estrobolome - SIBO· May 25, 2026· 16 min· Mechanistic inference
Why Does SIBO Keep Coming Back After Treatment?
Recurrent SIBO may represent an equilibrium state of an unaddressed host substrate failure. Antimicrobials reduce overgrowth without restoring the colonocyte bioenergetic capacity that defines which microbes can dominate. A Host Capacity Model reading of the recurrence cycle, the SLC5A8 / Fe-S / CD38-NAD+-SIRT3 mechanisms behind it, and what an HCM-anchored approach actually looks like.
#sibo#recurrent-sibo#host-capacity-model - Host Capacity Model· May 21, 2026· 23 min· Mechanistic inference
Why Probiotics Make You Sicker, Not Better: The Six Mechanisms Driving Probiotic Failure in MCAS, SIBO, Histamine Intolerance, and Long COVID, and Why The Field Has Been Asking The Wrong Question
What the research actually shows about why patients with chronic gut dysfunction react badly to the most widely recommended supplement in functional medicine, and where the actual lesion lives.
#probiotics#histamine#d-lactate - MCAS & Mast Cells· May 14, 2026· 26 min· Mechanistic inference
Histamine Intolerance: Why the DAO Enzyme Story Is Incomplete, and the Real Reason Your Low Histamine Diet Stopped Working
What standard explanations miss about bacterial histamine, the second breakdown enzyme almost nobody discusses, and why mast cell driven reactivity sits on a layer none of these interventions reach.
#histamine#mcas#dao - Host Capacity Model· May 14, 2026· 25 min· Mechanistic inference
Why Your Stool Test Doesn't Match Your Symptoms: The Mechanistic Limits of GI-MAP, BiomeFx, and Comprehensive Stool Analysis
What GI-MAP, BiomeFx, Genova, and comprehensive stool panels actually measure, what they cannot, and how to read your own gut when the report falls short.
#stool-testing#gi-map#biomefx
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