- Host Capacity Model·June 11, 2026· 28 min·Mechanistic inferenceEducational only
Why Dysbiosis, SIBO, Hydrogen Sulfide Intolerance, MCAS, and Long COVID May All Be Downstream of a Single Event
Dysbiosis, SIBO, hydrogen sulfide intolerance, MCAS, and long COVID may all be downstream of one event: the colonocyte losing control of oxygen, butyrate, and its own mitochondria. The Host Capacity Model in full.
#host-capacity-model#colonocyte#butyrate#mitochondria#dysbiosis#sibo#hydrogen-sulfide#mcas#long-covid#peroxynitrite#iron-sulfur-clusters#nad#cd38#glutathione#slc5a8#oxia-dysbiosis-loop#ppar-gamma#hif#cardiolipin#ferroptosisRead mechanism → - SIBO·June 1, 2026· 22 min·Mechanistic inferenceEducational only
What Actually Causes GERD and Acid Reflux? Why Long-Term PPI Use Often Makes It Worse
GERD is rarely too much acid. It's lower esophageal sphincter dysfunction with pressure from SIBO, gastroparesis, vagal compromise, and bioenergetic failure. Long-term PPI use often perpetuates the underlying disease through rebound hypersecretion and SIBO induction.
#gerd#acid-reflux#ppi#proton-pump-inhibitor#omeprazole#sibo#rebound-acid-hypersecretion#host-capacity-model#lower-esophageal-sphincter#hiatal-hernia#b12-deficiency#magnesium#ppi-dementia#famotidine#dglRead mechanism → - Frameworks·June 1, 2026· 22 min·HCM interpretationEducational only
What Actually Causes Fibromyalgia? The Mitochondrial, Mast Cell, and Small Fiber Neuropathy Mechanisms Standard Treatment Misses
Fibromyalgia has four upstream drivers: mitochondrial dysfunction, mast cell activation, small fiber neuropathy, and gut-brain axis dysfunction. Lyrica and Cymbalta act on central amplification, not on the peripheral lesions producing the input — which is why response is so often partial.
#fibromyalgia#chronic-pain#mitochondrial-dysfunction#mast-cells#small-fiber-neuropathy#gut-brain-axis#host-capacity-model#lyrica#cymbalta#central-sensitization#post-exertional-malaise#mcas#sibo#oaklander#cd38Read mechanism → - Frameworks·May 31, 2026· 22 min·HCM interpretationEducational only
What Actually Causes Chronic Migraine? A Mechanistic Reading of Treatment-Resistant Migraine
Chronic migraine has four upstream drivers: mitochondrial bioenergetic failure, dural mast cell activation, gut-brain axis dysfunction, and hormonal-vasomotor instability. Most treatment-resistant cases (including CGRP antibody non-responders) need the dominant driver addressed at its upstream point.
#chronic-migraine#migraine#cgrp#vestibular-migraine#hormonal-migraine#mitochondrial-dysfunction#mast-cells#gut-brain-axis#host-capacity-model#mcas#sibo#riboflavin#coq10#perimenopause#treatment-resistant-migraineRead mechanism → - Fertility·May 30, 2026· 21 min·Mechanistic inferenceEducational only
Why Does Endometriosis Come Back After Surgery? The Gut, Estrobolome, and Bioenergetic Mechanism
Endometriosis recurs because excision removes lesions but not the substrate that selected for them. A mechanistic reading of the gut estrobolome, beta-glucuronidase-driven estrogen recirculation, LPS-driven inflammation, pelvic mast cell infiltration, mitochondrial dysfunction, and iron-driven oxidative damage — and why surgery and hormonal suppression contain the disease but rarely resolve it.
#endometriosis#endometriosis-recurrence#estrobolome#beta-glucuronidase#gut-microbiome#host-capacity-model#sibo#mcas#lps#mast-cells#mitochondrial-dysfunction#perimenopause#womens-health#hormonal-healthRead mechanism → - SIBO·May 25, 2026· 16 min·Mechanistic inferenceEducational only
Why Does SIBO Keep Coming Back After Treatment?
Recurrent SIBO is the equilibrium state of an unaddressed host substrate failure. Antimicrobials reduce overgrowth without restoring the colonocyte bioenergetic capacity that defines which microbes can dominate. A Host Capacity Model reading of the recurrence cycle, the SLC5A8 / Fe-S / CD38-NAD+-SIRT3 mechanisms behind it, and what an HCM-anchored approach actually looks like.
#sibo#recurrent-sibo#host-capacity-model#dysbiosis#h2s-sibo#methane-sibo#rifaximin#case-reasoning#mechanism#colonocyte-bioenergetics#nad#sirt3#cd38#slc5a8Read mechanism → - MCAS & Mast Cells·May 14, 2026· 26 min·Mechanistic inferenceEducational only
Histamine Intolerance: Why the DAO Enzyme Story Is Incomplete, and the Real Reason Your Low Histamine Diet Stopped Working
What standard explanations miss about bacterial histamine, the second breakdown enzyme almost nobody discusses, and why mast cell driven reactivity sits on a layer none of these interventions reach.
#histamine#mcas#dao#hnmt#mast-cells#methylation#host-capacity#siboRead mechanism → - Host Capacity Model·May 14, 2026· 25 min·Mechanistic inferenceEducational only
Why Your Stool Test Doesn't Match Your Symptoms: The Mechanistic Limits of GI-MAP, BiomeFx, and Comprehensive Stool Analysis
What GI-MAP, BiomeFx, Genova, and comprehensive stool panels actually measure, what they cannot, and how to read your own gut when the report falls short.
#stool-testing#gi-map#biomefx#dysbiosis#host-capacity#case-reasoning#siboRead mechanism → - Host Capacity Model·May 14, 2026· 22 min·Mechanistic inferenceEducational only
Why Every Protocol Stops Working After Two Weeks: The Mechanistic Pattern Hiding in Plain Sight in Chronic SIBO, MCAS, and Long COVID
The pattern nobody has named — and what it's actually telling you about your upstream lesion. Why pharmacologically unrelated protocols all plateau on the same two-to-three-week curve, and what that convergence reveals about where your lesion actually lives.
#host-capacity#sibo#mcas#long-covid#protocol-failure#case-reasoningRead mechanism → - SIBO·May 5, 2026· 21 min·Literature-supported mechanismEducational only
Why SIBO Breath Tests Are Fundamentally Unreliable: And How to Actually Identify What's Happening in Your Gut
The Problem Nobody Wants to Say Out Loud
#siboRead mechanism → - SIBO·May 2, 2026· 20 min·Literature-supported mechanismEducational only
The Hidden Driver of SIBO and Chronic Gut Dysfunction: Bile Acid Malabsorption, Dysbiosis, and the Mitochondrial Cascade
The Overlooked Mechanism That Defines Treatment Failure
#sibo#mitochondri#bile#dysbiosisRead mechanism → - SIBO·April 28, 2026· 11 min·Mechanistic inferenceEducational only
The Single Molecule Driving Both Your SIBO and Your MCAS (And Why Nothing Has Worked)
If you have IBS, and MCAS, and maybe SIBO and you ve been told these are three separate problems that just happen to co-occur in unlucky people like you I want to show you something.
#sibo#mcas#dysbiosis#fodmapRead mechanism → - SIBO·April 16, 2026· 40 min·HCM interpretationEducational only
The Real Cause of SIBO — Why Everything You’ve Been Told Is Incomplete
By Mohammed Attallah | Biomelogic | Host Capacity Model
#sibo#fodmapRead mechanism → - SIBO·April 15, 2026· 4 min·Mechanistic inferenceEducational only
Why Some People Never Recover From Gut Disorders: The Overlooked Genetic Architecture Driving Butyrate Failure, Dysbiosis, and Chronic Symptoms
Most people still talk about SIBO, IBS, hydrogen sulfide overgrowth, or post-infectious gut dysfunction as if the microbiome alone is the entire story.
#sibo#mitochondri#butyrate#dysbiosis#colonocyteRead mechanism → - SIBO·April 14, 2026· 15 min·Mechanistic inferenceEducational only
When the Virus Leaves But the Lock Stays: Post-Viral Epigenetic Silencing in Gut Dysfunction and…
When the Virus Leaves But the Lock Stays: Post-Viral Epigenetic Silencing in Gut Dysfunction and the Pharmacological Case for HDAC Inhibition A mechanistic investigation for clinicians — educational purposes only. Not a clinical framework. Not a prescription endorsement. The Parad
#sibo#dysbiosis#colonocyteRead mechanism →
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