The limits are published alongside the reasoning.
- Evidence tiers
Every article carries an explicit evidence tier, so established biology is never presented as if it were clinical proof.
Read the claim ledger - What this does not prove
Mechanistic pieces are required to state their own limits and the competing explanations that would fit the same data.
See the counterarguments - Published corrections
Where the reasoning has been revised, the revision is recorded rather than quietly edited away.
Review the standards
Pick the sentence that sounds like your situation.
- Why does my SIBO keep coming back?
- Are SIBO breath tests actually reliable?
- Why don't antihistamines settle my symptoms?
- Can I have mast cell activation with normal tryptase?
- Why won't my Long COVID symptoms resolve?
- Why did COVID trigger this in me and not others?
- Why are my labs normal when I feel terrible?
- Why doesn't my stool test match my symptoms?
- Why does every protocol stop working after two weeks?
- Why did butyrate or probiotics make me worse?
- What do bile acids have to do with my gut symptoms?
- Can gut health affect my hormones and egg quality?
Educational mechanistic writing. It does not diagnose, and it does not replace the clinician treating you.
Seven mechanistic threads run through this library.
Recurrent SIBO & breath-test interpretation
13 articles · recurrent SIBO
Mast-cell activation, tryptase & histamine
17 articles · mast cell activation
Long COVID, post-viral gut–immune & POTS
12 articles · Long COVID gut symptoms
Colonocyte bioenergetics, butyrate & oxygen
18 articles · colonocyte bioenergetics
Bile acids, TUDCA & C. difficile ecology
5 articles · bile acid dysfunction
Gut–hormone axis, fertility & estrobolome
3 articles · gut microbiome and fertility
Lab-pattern interpretation
5 articles · lab pattern interpretation
3 articles
- Host Capacity Model· August 5, 2026· 6 min· Mechanistic inference
Why Dysbiosis Keeps Coming Back: The Overlooked Vitamin B2–Butyrate–Oxygen Connection
Riboflavin sits in the electron-transfer chemistry that lets colonocytes burn butyrate and hold the colon hypoxic. A mechanistic account of why dysbiosis recurs when that oxygen-consuming step is limited.
#riboflavin#vitamin-b2#butyrate - SIBO· April 11, 2026· 10 min· Mechanistic inference
Your SIBO Subtype Doesn't Matter — Until You Fix the Cell That Created It
Hydrogen, methane and hydrogen sulfide describe which organisms expanded, not why the terrain allowed it. Why subtype-directed treatment keeps failing when the upstream epithelial failure is untouched.
#sibo#hydrogen#methane - Host Capacity Model· March 31, 2026· 12 min· Mechanistic inference
What Pregnancy Teaches Us About Why SIBO Treatments Often Fail
Pregnancy changes motility, immune tolerance and bioenergetic demand at once — which is why it exposes the host-side variables that SIBO treatment usually ignores.
#pregnancy#sibo#progesterone
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