- Frameworks·May 31, 2026· 22 min·HCM interpretationEducational only
What Actually Causes Chronic Migraine? A Mechanistic Reading of Treatment-Resistant Migraine
Chronic migraine has four upstream drivers: mitochondrial bioenergetic failure, dural mast cell activation, gut-brain axis dysfunction, and hormonal-vasomotor instability. Most treatment-resistant cases (including CGRP antibody non-responders) need the dominant driver addressed at its upstream point.
#chronic-migraine#migraine#cgrp#vestibular-migraine#hormonal-migraine#mitochondrial-dysfunction#mast-cells#gut-brain-axis#host-capacity-model#mcas#sibo#riboflavin#coq10#perimenopause#treatment-resistant-migraineRead mechanism → - Fertility·May 30, 2026· 21 min·Mechanistic inferenceEducational only
Why Does Endometriosis Come Back After Surgery? The Gut, Estrobolome, and Bioenergetic Mechanism
Endometriosis recurs because excision removes lesions but not the substrate that selected for them. A mechanistic reading of the gut estrobolome, beta-glucuronidase-driven estrogen recirculation, LPS-driven inflammation, pelvic mast cell infiltration, mitochondrial dysfunction, and iron-driven oxidative damage — and why surgery and hormonal suppression contain the disease but rarely resolve it.
#endometriosis#endometriosis-recurrence#estrobolome#beta-glucuronidase#gut-microbiome#host-capacity-model#sibo#mcas#lps#mast-cells#mitochondrial-dysfunction#perimenopause#womens-health#hormonal-healthRead mechanism → - Host Capacity Model·May 14, 2026· 32 min·Mechanistic inferenceEducational only
Why Your Chronic Illness Got Dramatically Worse in Perimenopause: The Hormonal Cascade Driving Gut, Mast Cell, Brain Fog, and Fatigue Symptoms in Your 40s
What the research now shows about why women in their 40s experience the emergence or sudden worsening of MCAS, histamine intolerance, SIBO, autoimmune flares, and post viral illness, and where the actual upstream lesion lives.
#perimenopause#mcas#histamine#hpa-axis#mitochondria#estrobolome#host-capacity#hrt#case-reasoningRead mechanism →
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