The limits are published alongside the reasoning.
- Evidence tiers
Every article carries an explicit evidence tier, so established biology is never presented as if it were clinical proof.
Read the claim ledger - What this does not prove
Mechanistic pieces are required to state their own limits and the competing explanations that would fit the same data.
See the counterarguments - Published corrections
Where the reasoning has been revised, the revision is recorded rather than quietly edited away.
Review the standards
Pick the sentence that sounds like your situation.
- Why does my SIBO keep coming back?
- Are SIBO breath tests actually reliable?
- Why don't antihistamines settle my symptoms?
- Can I have mast cell activation with normal tryptase?
- Why won't my Long COVID symptoms resolve?
- Why did COVID trigger this in me and not others?
- Why are my labs normal when I feel terrible?
- Why doesn't my stool test match my symptoms?
- Why does every protocol stop working after two weeks?
- Why did butyrate or probiotics make me worse?
- What do bile acids have to do with my gut symptoms?
- Can gut health affect my hormones and egg quality?
Educational mechanistic writing. It does not diagnose, and it does not replace the clinician treating you.
Seven mechanistic threads run through this library.
Recurrent SIBO & breath-test interpretation
14 articles · recurrent SIBO
Mast-cell activation, tryptase & histamine
19 articles · mast cell activation
Long COVID, post-viral gut–immune & POTS
13 articles · Long COVID gut symptoms
Colonocyte bioenergetics, butyrate & oxygen
19 articles · colonocyte bioenergetics
Bile acids, TUDCA & C. difficile ecology
5 articles · bile acid dysfunction
Gut–hormone axis, fertility & estrobolome
3 articles · gut microbiome and fertility
Lab-pattern interpretation
6 articles · lab pattern interpretation
7 articles
- Host Capacity Model· August 5, 2026· 6 min· Mechanistic inference
Why Dysbiosis Keeps Coming Back: The Overlooked Vitamin B2–Butyrate–Oxygen Connection
Riboflavin sits in the electron-transfer chemistry that lets colonocytes burn butyrate and hold the colon hypoxic. A mechanistic account of why dysbiosis recurs when that oxygen-consuming step is limited.
#riboflavin#vitamin-b2#butyrate - MCAS & Mast Cells· July 17, 2026· 28 min· Mechanistic inference
Rethinking Chronic Dysbiosis, Mast Cell Activation, and the Failure of Intestinal Ecological Control
Why the microbiome may remain unstable until the intestinal epithelium regains the capacity to metabolize microbial products, consume oxygen, regulate inflammation, and rebuild itself
#dysbiosis#mast-cells#mcas - Mitochondria· May 25, 2026· 5 min· Mechanistic inference
Ulcerative Colitis Starts in the Mitochondrion
For forty years the field treated UC as immune dysregulation. The 2024 and 2025 literature finally admits what was upstream all along.
#ulcerative-colitis#ibd#mitochondria - Host Capacity Model· May 14, 2026· 12 min· Mechanistic inference
The Mycotoxin-Mitochondria Trap: Why Standard Detox Fails in Chronic Illness, and How to Escape It
Mycotoxins directly impair mitochondrial function and disrupt the gut oxygen gradient, creating a bioenergetic trap that binders alone cannot break. A Host Capacity Model interpretation of why standard detox protocols fail in SIBO, MCAS, and long COVID, and what the upstream lesion actually requires.
#mycotoxins#mitochondria#colonocyte-bioenergetics - SIBO· April 11, 2026· 10 min· Mechanistic inference
Your SIBO Subtype Doesn't Matter — Until You Fix the Cell That Created It
Hydrogen, methane and hydrogen sulfide describe which organisms expanded, not why the terrain allowed it. Why subtype-directed treatment keeps failing when the upstream epithelial failure is untouched.
#sibo#hydrogen#methane - Host Capacity Model· March 27, 2026· 13 min· Mechanistic inference
Why Your Gut Won't Heal: The Real Reason Chronic Gut Problems Keep Coming Back
Diets, antimicrobials and probiotics can move the microbial picture without changing the host environment that produced it. A plain-language mechanistic reading of why the same dysbiosis pattern keeps rebuilding itself after treatment.
#dysbiosis#sibo#gut-healing - Host Capacity Model· December 19, 2025· 5 min· Mechanistic inference
Your Gut Bacteria Don’t Care What You Eat — They Care About Inflammation
Diet shapes substrate; inflammation and oxygen shape who can live there. Why long-term restrictive diets often fail to change the ecology they were meant to clarify.
#diet#low-fodmap#inflammation
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