The limits are published alongside the reasoning.
- Evidence tiers
Every article carries an explicit evidence tier, so established biology is never presented as if it were clinical proof.
Read the claim ledger - What this does not prove
Mechanistic pieces are required to state their own limits and the competing explanations that would fit the same data.
See the counterarguments - Published corrections
Where the reasoning has been revised, the revision is recorded rather than quietly edited away.
Review the standards
Pick the sentence that sounds like your situation.
- Why does my SIBO keep coming back?
- Are SIBO breath tests actually reliable?
- Why don't antihistamines settle my symptoms?
- Can I have mast cell activation with normal tryptase?
- Why won't my Long COVID symptoms resolve?
- Why did COVID trigger this in me and not others?
- Why are my labs normal when I feel terrible?
- Why doesn't my stool test match my symptoms?
- Why does every protocol stop working after two weeks?
- Why did butyrate or probiotics make me worse?
- What do bile acids have to do with my gut symptoms?
- Can gut health affect my hormones and egg quality?
Educational mechanistic writing. It does not diagnose, and it does not replace the clinician treating you.
Seven mechanistic threads run through this library.
Recurrent SIBO & breath-test interpretation
16 articles · recurrent SIBO
Mast-cell activation, tryptase & histamine
23 articles · mast cell activation
Long COVID, post-viral gut–immune & POTS
18 articles · Long COVID gut symptoms
Colonocyte bioenergetics, butyrate & oxygen
20 articles · colonocyte bioenergetics
Bile acids, TUDCA & C. difficile ecology
7 articles · bile acid dysfunction
Gut–hormone axis, fertility & estrobolome
8 articles · gut microbiome and fertility
Lab-pattern interpretation
6 articles · lab pattern interpretation
7 articles
- SIBO· September 17, 2026· 15 min· Mechanistic inference
The Mold Is Only Half the Story: Why the Host Determines the Toxicity
I have been working through a particularly complex mold-related case, and the deeper I went into the client’s history, laboratory testing, genetics, mitochondrial findings, gastrointestinal findings, supplement exposures, and older
#mold#bile-acids#hormones - MCAS & Mast Cells· September 16, 2026· 9 min· Mechanistic inference
Mold Is Not Just a Detoxification Problem — It Can Become a Resolution Problem
Mold illness is often approached as though the main biological problem is simply the continued presence of a toxin: identify the exposure, leave the environment, reduce further exposure, use binders when appropriate, support elimination
#histamine#mast-cells#mitochondria - MCAS & Mast Cells· September 10, 2026· 15 min· Mechanistic inference
Mold, Mast Cells, and the Protease Nobody Talks About: Chymase, MMP-9, and Vascular Remodeling When Tryptase Looks Normal
One mast cell mediator has become increasingly important in my research lately, particularly while working through a complex case involving longstanding urticaria, recurrent angioedema, delayed pressure swelling, gastrointestinal
#histamine#mast-cells#mold - SIBO· September 3, 2026· 17 min· Mechanistic inference
Mold Toxicity Is More Than Exposure: The Mitochondria–Gut–Immune Cascade Behind Chronic Illness
From my research into mold, mycotoxins, mitochondrial physiology, gut ecology, immune signaling and host genetics, and from the patterns I continue to examine while working through complex gastrointestinal, autonomic, neurological
#microbime#mast-cell-activation#mold - Case Reasoning· August 26, 2026· 18 min· Clinical pattern observation
Long COVID, MCAS, Mold, Heavy Metals, SIBO and Mitochondrial Collapse: A Case That Shows What Happens When We Treat the Target but Forget the Host
A complex case combining Long COVID, ME/CFS physiology, hyperadrenergic POTS, MCAS-type hyperreactivity, recurrent SIBO and methanogen overgrowth, mycotoxin findings, elevated toxic metals and profound mitochondrial respiratory-chain impairment — read as a single host-capacity failure rather than a list of separate targets.
#long-covid#me-cfs#hyperadrenergic-pots - Host Capacity Model· August 12, 2026· 20 min· Mechanistic inference
Mold, Mycotoxins, SIBO, and Chronic Illness: How Enteric Nervous System Dysfunction and Loss of Host Capacity Create a Self-Reinforcing Biological Loop
How mycotoxin exposure, enteric nervous system dysfunction and loss of host capacity can form a self-reinforcing loop behind recurrent SIBO, methanogen overgrowth and severe constipation.
#mold#mycotoxins#sibo - MCAS & Mast Cells· May 26, 2026· 18 min· Mechanistic inference
Why Does MCAS Not Respond to Standard Treatment? The Four Mechanistically Distinct Patterns
Treatment-resistant MCAS may, in a subset of people, be a stratification problem rather than a stabilization problem. At least four candidate mechanistic patterns can contribute to the MCAS phenotype — barrier-driven, neuroimmune/vagal, chemical/toxicant, and clonal/KIT-driven — and they require different upstream interventions. A Host Capacity Model reading of why cromolyn, ketotifen, and the standard stack fail, and what stratification-anchored care looks like.
#mcas#mast-cell-activation-syndrome#treatment-resistant-mcas
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