- Frameworks·June 1, 2026· 22 min·HCM interpretationEducational only
What Actually Causes Fibromyalgia? The Mitochondrial, Mast Cell, and Small Fiber Neuropathy Mechanisms Standard Treatment Misses
Fibromyalgia has four upstream drivers: mitochondrial dysfunction, mast cell activation, small fiber neuropathy, and gut-brain axis dysfunction. Lyrica and Cymbalta act on central amplification, not on the peripheral lesions producing the input — which is why response is so often partial.
#fibromyalgia#chronic-pain#mitochondrial-dysfunction#mast-cells#small-fiber-neuropathy#gut-brain-axis#host-capacity-model#lyrica#cymbalta#central-sensitization#post-exertional-malaise#mcas#sibo#oaklander#cd38Read mechanism → - Frameworks·May 31, 2026· 22 min·HCM interpretationEducational only
What Actually Causes Chronic Migraine? A Mechanistic Reading of Treatment-Resistant Migraine
Chronic migraine has four upstream drivers: mitochondrial bioenergetic failure, dural mast cell activation, gut-brain axis dysfunction, and hormonal-vasomotor instability. Most treatment-resistant cases (including CGRP antibody non-responders) need the dominant driver addressed at its upstream point.
#chronic-migraine#migraine#cgrp#vestibular-migraine#hormonal-migraine#mitochondrial-dysfunction#mast-cells#gut-brain-axis#host-capacity-model#mcas#sibo#riboflavin#coq10#perimenopause#treatment-resistant-migraineRead mechanism → - Fertility·May 30, 2026· 21 min·Mechanistic inferenceEducational only
Why Does Endometriosis Come Back After Surgery? The Gut, Estrobolome, and Bioenergetic Mechanism
Endometriosis recurs because excision removes lesions but not the substrate that selected for them. A mechanistic reading of the gut estrobolome, beta-glucuronidase-driven estrogen recirculation, LPS-driven inflammation, pelvic mast cell infiltration, mitochondrial dysfunction, and iron-driven oxidative damage — and why surgery and hormonal suppression contain the disease but rarely resolve it.
#endometriosis#endometriosis-recurrence#estrobolome#beta-glucuronidase#gut-microbiome#host-capacity-model#sibo#mcas#lps#mast-cells#mitochondrial-dysfunction#perimenopause#womens-health#hormonal-healthRead mechanism → - Frameworks·May 29, 2026· 21 min·HCM interpretationEducational only
What Actually Causes IBD? A Mechanistic Reading of Crohn's Disease and Ulcerative Colitis
IBD is not a single autoimmune disease. At the cellular level both Crohn's and ulcerative colitis are dominated by colonocyte bioenergetic failure — loss of butyrate oxidation, collapse of the gut oxygen gradient, and the inflammatory cascade that follows. A mechanistic reading anchored in primary research from Roediger 1990 onward, and why standard immunosuppression contains the response but does not restore the upstream lesion.
#ibd#crohns-disease#ulcerative-colitis#inflammatory-bowel-disease#biologics#colonocyte-bioenergetics#host-capacity-model#butyrate#slc5a8#faecalibacterium-prausnitzii#akkermansia#mitochondrial-dysfunction#cd38#nadRead mechanism → - Frameworks·May 27, 2026· 19 min·HCM interpretationEducational only
Why Am I So Tired When My Blood Work Is Normal? What Standard Testing Misses
Normal labs and persistent symptoms is not a contradiction. The lesion is usually in a layer the standard panel does not measure. A Host Capacity Model reading of why conventional blood work returns normal while chronic illness continues, the specific cellular, mitochondrial, gut, and autonomic mechanisms involved, and what testing actually catches what is missed.
#chronic-fatigue#normal-labs#blood-work#host-capacity-model#functional-medicine-testing#cellular-bioenergetics#mitochondrial-dysfunction#medically-unexplained-symptoms#cd38#nad#sirt3Read mechanism →
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