The limits are published alongside the reasoning.
- Evidence tiers
Every article carries an explicit evidence tier, so established biology is never presented as if it were clinical proof.
Read the claim ledger - What this does not prove
Mechanistic pieces are required to state their own limits and the competing explanations that would fit the same data.
See the counterarguments - Published corrections
Where the reasoning has been revised, the revision is recorded rather than quietly edited away.
Review the standards
Pick the sentence that sounds like your situation.
- Why does my SIBO keep coming back?
- Are SIBO breath tests actually reliable?
- Why don't antihistamines settle my symptoms?
- Can I have mast cell activation with normal tryptase?
- Why won't my Long COVID symptoms resolve?
- Why did COVID trigger this in me and not others?
- Why are my labs normal when I feel terrible?
- Why doesn't my stool test match my symptoms?
- Why does every protocol stop working after two weeks?
- Why did butyrate or probiotics make me worse?
- What do bile acids have to do with my gut symptoms?
- Can gut health affect my hormones and egg quality?
Educational mechanistic writing. It does not diagnose, and it does not replace the clinician treating you.
Seven mechanistic threads run through this library.
Recurrent SIBO & breath-test interpretation
16 articles · recurrent SIBO
Mast-cell activation, tryptase & histamine
23 articles · mast cell activation
Long COVID, post-viral gut–immune & POTS
18 articles · Long COVID gut symptoms
Colonocyte bioenergetics, butyrate & oxygen
20 articles · colonocyte bioenergetics
Bile acids, TUDCA & C. difficile ecology
7 articles · bile acid dysfunction
Gut–hormone axis, fertility & estrobolome
8 articles · gut microbiome and fertility
Lab-pattern interpretation
6 articles · lab pattern interpretation
36 articles · showing 12
- MCAS & Mast Cells· October 23, 2026· 28 min· Mechanistic inference
Why Progesterone Calms One Woman but Sends Another Into Panic: The Hidden Biology of Hormonal Sensitivity
Why women can experience severe anxiety, insomnia, panic, and emotional changes despite normal hormone tests—and what allopregnanolone, GABA receptors, childhood trauma, neuroinflammation
#hormone#gut#progesterone - SIBO· October 22, 2026· 31 min· Mechanistic inference
Facial Flushing, Racing Heart, Gut Pain, and Crashing After Meals: Could Excess Gut Serotonin Be Driving Mast Cell Activation?
The hidden connection between serotonin overload, Prevotella copri, impaired serotonin clearance, and the gut–immune–nervous system.
#mast-cell-activation#gut-health#sertonin - MCAS & Mast Cells· October 20, 2026· 28 min· Mechanistic inference
Immunoadsorption (IA): The German Therapy That Removes Autoantibodies From the Blood — Could It Change the Future of Autoimmune Disease?
Over the past several months, I have been spending considerable time investigating a treatment called immunoadsorption, commonly abbreviated as IA.
#mcas#long-covid#dysautonomia - MCAS & Mast Cells· September 16, 2026· 10 min· Mechanistic inference
10 Things I Learned About Mast Cells That Changed How I Understand MCAS
The more I study mast cells and work through complex cases, the less useful it becomes to think of them simply as “histamine cells.” Histamine is important, but mast cells are much more sophisticated than that.
#mcas#histamine#mast-cells - SIBO· September 7, 2026· 35 min· Mechanistic inference
The Histamine Problem Nobody Explains: Why Some People Suddenly Start Reacting to Everything
The more I research histamine, and the more I work through complex cases involving MCAS, POTS, dysautonomia, SIBO, food reactions, gastrointestinal dysfunction, hormonal changes, medication sensitivities, flushing, itching, headaches
#sibo#mcas#histamine - MCAS & Mast Cells· August 31, 2026· 20 min· Mechanistic inference
The Post-COVID Ciprofloxacin Injury Neuroimmune Trap: Bladder Dysfunction, Small-Fiber Neuropathy, MRGPRX2 Mast Cells, HLA Genetics, Mitochondria and the Gut-Brain Axis
I recently had a discovery call with a complex post-COVID client whose case made me look much more deeply at how the bladder, peripheral nervous system, autonomic nervous system, mast cells, mitochondria, vascular system, immune tolerance
#mcas#ciprofloxacin#hla - MCAS & Mast Cells· August 27, 2026· 18 min· Mechanistic inference
The Antihistamine–Stomach Acid Connection: Why Low Acid Is Often a Signaling Problem, Not Just a Digestion Problem
Long-term acid suppression and H2 antihistamines act on the same histamine signal that parietal cells use to secrete acid. A mechanistic look at why persistent reflux, early fullness, poor protein tolerance, iron and B12 abnormalities and recurrent dysbiosis can follow — and why low stomach acid is often a signalling problem rather than a digestion problem.
#histamine#h2-receptor#stomach-acid - Case Reasoning· August 26, 2026· 18 min· Clinical pattern observation
Long COVID, MCAS, Mold, Heavy Metals, SIBO and Mitochondrial Collapse: A Case That Shows What Happens When We Treat the Target but Forget the Host
A complex case combining Long COVID, ME/CFS physiology, hyperadrenergic POTS, MCAS-type hyperreactivity, recurrent SIBO and methanogen overgrowth, mycotoxin findings, elevated toxic metals and profound mitochondrial respiratory-chain impairment — read as a single host-capacity failure rather than a list of separate targets.
#long-covid#me-cfs#hyperadrenergic-pots - MCAS & Mast Cells· August 11, 2026· 13 min· Mechanistic inference
Why a Normal Tryptase Can Miss Mast Cell Activation: A More Precise Testing Framework
A normal baseline tryptase answers a narrower question than most people assume. A more precise framework for what mast-cell mediator testing can and cannot rule out, including timing, handling and mediator selection.
#tryptase#mcas#mast-cell-activation - MCAS & Mast Cells· August 6, 2026· 4 min· Mechanistic inference
Your Mast Cells May Be Reacting to a Gut That Never Stopped Signaling Danger
Mast cells rarely become reactive without an input. A short reading of the gut-derived signalling that keeps them primed, and why that reframes mast-cell symptoms as downstream rather than primary.
#mast-cells#mcas#dysbiosis - Case Reasoning· August 3, 2026· 12 min· Clinical pattern observation
The Microbial Metabolites That May Be Rewiring the Brain: The Hidden Link Between SIBO, IBS, MCAS, Autism, ADHD, Glutamate, and Catecholamine Dysfunction
HPHPA, hydrogen sulfide, D-lactate and ammonia are microbial metabolites that may pressure catecholamine regulation through dopamine β-hydroxylase, COMT and mitochondrial ATP. A case-anchored look at the hidden link between SIBO, IBS, MCAS, POTS, ADHD-like symptoms and autism-spectrum features — a metabolite-driven mechanism rather than a purely compositional dysbiosis.
#hphpa#clostridia#dopamine-beta-hydroxylase - Frameworks· July 30, 2026· 11 min· HCM interpretation
SIBO, MCAS, POTS and Food Intolerance May Be One Self-Sustaining System
For years, SIBO, MCAS, POTS, dysautonomia, food intolerance, chronic fatigue, neurological symptoms, and mitochondrial dysfunction have been treated as separate diagnoses.
#sibo#mcas#pots
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