The limits are published alongside the reasoning.
- Evidence tiers
Every article carries an explicit evidence tier, so established biology is never presented as if it were clinical proof.
Read the claim ledger - What this does not prove
Mechanistic pieces are required to state their own limits and the competing explanations that would fit the same data.
See the counterarguments - Published corrections
Where the reasoning has been revised, the revision is recorded rather than quietly edited away.
Review the standards
Pick the sentence that sounds like your situation.
- Why does my SIBO keep coming back?
- Are SIBO breath tests actually reliable?
- Why don't antihistamines settle my symptoms?
- Can I have mast cell activation with normal tryptase?
- Why won't my Long COVID symptoms resolve?
- Why did COVID trigger this in me and not others?
- Why are my labs normal when I feel terrible?
- Why doesn't my stool test match my symptoms?
- Why does every protocol stop working after two weeks?
- Why did butyrate or probiotics make me worse?
- What do bile acids have to do with my gut symptoms?
- Can gut health affect my hormones and egg quality?
Educational mechanistic writing. It does not diagnose, and it does not replace the clinician treating you.
Seven mechanistic threads run through this library.
Recurrent SIBO & breath-test interpretation
16 articles · recurrent SIBO
Mast-cell activation, tryptase & histamine
23 articles · mast cell activation
Long COVID, post-viral gut–immune & POTS
18 articles · Long COVID gut symptoms
Colonocyte bioenergetics, butyrate & oxygen
20 articles · colonocyte bioenergetics
Bile acids, TUDCA & C. difficile ecology
7 articles · bile acid dysfunction
Gut–hormone axis, fertility & estrobolome
8 articles · gut microbiome and fertility
Lab-pattern interpretation
6 articles · lab pattern interpretation
27 articles · showing 12
- SIBO· October 24, 2026· 13 min· Mechanistic inference
The Bile Acid–Estrogen Connection: A Missing Piece in Women’s Hormonal and Gut Health
One of the most interesting patterns I’ve been investigating through my work with women experiencing hormonal changes, gastrointestinal dysfunction, and complex chronic illness involves something that often receives very little attention
#histamine#mast-cells#bile-acids - MCAS & Mast Cells· October 23, 2026· 28 min· Mechanistic inference
Why Progesterone Calms One Woman but Sends Another Into Panic: The Hidden Biology of Hormonal Sensitivity
Why women can experience severe anxiety, insomnia, panic, and emotional changes despite normal hormone tests—and what allopregnanolone, GABA receptors, childhood trauma, neuroinflammation
#hormone#gut#progesterone - SIBO· October 22, 2026· 31 min· Mechanistic inference
Facial Flushing, Racing Heart, Gut Pain, and Crashing After Meals: Could Excess Gut Serotonin Be Driving Mast Cell Activation?
The hidden connection between serotonin overload, Prevotella copri, impaired serotonin clearance, and the gut–immune–nervous system.
#mast-cell-activation#gut-health#sertonin - MCAS & Mast Cells· October 21, 2026· 7 min· Mechanistic inference
Why Progesterone Can Calm One Woman and Make Another Worse: The Overlooked Connection Between Trauma, Allopregnanolone, Mast Cells, and Women's Brain Health
Something I hear frequently from women I work with is the frustration of receiving a diagnosis, being prescribed a hormone or medication, and then experiencing symptoms that nobody seems able to explain.
#histamine#mast-cells#estrogen - MCAS & Mast Cells· October 17, 2026· 5 min· Mechanistic inference
The Estrogen–Histamine Connection: Why I Look Beyond DAO and Histamine Levels
Something I frequently notice when working with clients experiencing histamine intolerance, mast cell-related symptoms, and chronic gastrointestinal dysfunction is elevated estradiol.
#histamine#mast-cells#estrogen - MCAS & Mast Cells· September 16, 2026· 9 min· Mechanistic inference
Mold Is Not Just a Detoxification Problem — It Can Become a Resolution Problem
Mold illness is often approached as though the main biological problem is simply the continued presence of a toxin: identify the exposure, leave the environment, reduce further exposure, use binders when appropriate, support elimination
#histamine#mast-cells#mitochondria - MCAS & Mast Cells· September 16, 2026· 10 min· Mechanistic inference
10 Things I Learned About Mast Cells That Changed How I Understand MCAS
The more I study mast cells and work through complex cases, the less useful it becomes to think of them simply as “histamine cells.” Histamine is important, but mast cells are much more sophisticated than that.
#mcas#histamine#mast-cells - Mitochondria· September 15, 2026· 15 min· Mechanistic inference
The Pathogen Is Only the Beginning: 10 Things My Research Into Lyme and Bartonella Is Changing About How I Understand Chronic Illness
The deeper I go into Lyme disease and Bartonella, the more convinced I become that identifying the organism is only the first layer of the problem.
#mast-cells#pots#mitochondria - SIBO· September 14, 2026· 19 min· Mechanistic inference
ME/CFS, Butyrate, and Host Capacity: What a Severe Case Reveals About the Microbiome–Host Relationship
I have been studying the gastrointestinal physiology of ME/CFS for some time, but a severe long-duration case I am currently analyzing has pushed me to think much more carefully about what we actually mean when we say that the microbiome
#sibo#histamine#mast-cells - MCAS & Mast Cells· September 10, 2026· 15 min· Mechanistic inference
Mold, Mast Cells, and the Protease Nobody Talks About: Chymase, MMP-9, and Vascular Remodeling When Tryptase Looks Normal
One mast cell mediator has become increasingly important in my research lately, particularly while working through a complex case involving longstanding urticaria, recurrent angioedema, delayed pressure swelling, gastrointestinal
#histamine#mast-cells#mold - SIBO· September 7, 2026· 35 min· Mechanistic inference
The Histamine Problem Nobody Explains: Why Some People Suddenly Start Reacting to Everything
The more I research histamine, and the more I work through complex cases involving MCAS, POTS, dysautonomia, SIBO, food reactions, gastrointestinal dysfunction, hormonal changes, medication sensitivities, flushing, itching, headaches
#sibo#mcas#histamine - SIBO· September 3, 2026· 17 min· Mechanistic inference
Mold Toxicity Is More Than Exposure: The Mitochondria–Gut–Immune Cascade Behind Chronic Illness
From my research into mold, mycotoxins, mitochondrial physiology, gut ecology, immune signaling and host genetics, and from the patterns I continue to examine while working through complex gastrointestinal, autonomic, neurological
#microbime#mast-cell-activation#mold
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