9 articles
- Frameworks· July 30, 2026· 11 min· HCM interpretation
SIBO, MCAS, POTS and Food Intolerance May Be One Self-Sustaining System
For years, SIBO, MCAS, POTS, dysautonomia, food intolerance, chronic fatigue, neurological symptoms, and mitochondrial dysfunction have been treated as separate diagnoses.
#sibo#mcas#pots - MCAS & Mast Cells· July 17, 2026· 28 min· Mechanistic inference
Rethinking Chronic Dysbiosis, Mast Cell Activation, and the Failure of Intestinal Ecological Control
Why the microbiome may remain unstable until the intestinal epithelium regains the capacity to metabolize microbial products, consume oxygen, regulate inflammation, and rebuild itself
#dysbiosis#mast-cells#mcas - MCAS & Mast Cells· June 9, 2026· 13 min· Mechanistic inference
Why Mast Cell Activation May Be the Last Domino, Not the First — A Systems-Biology Reframe of MCAS
For decades, the mast cell has carried a reputation it may not fully deserve. We learned it as the cell of allergy: the histamine grenade, the hive, the wheeze, the anaphylactic emergency. In that framing, Mast Cell Activation Syndrome (MCAS) becomes a straightforward story —…
#mcas#mast-cells#systems-biology - Frameworks· June 1, 2026· 22 min· HCM interpretation
What May Be Driving Fibromyalgia? The Mitochondrial, Mast Cell, and Small Fiber Neuropathy Mechanisms Standard Treatment Misses
Fibromyalgia has four upstream drivers: mitochondrial dysfunction, mast cell activation, small fiber neuropathy, and gut-brain axis dysfunction. Lyrica and Cymbalta act on central amplification, not on the peripheral lesions producing the input — which is why response is so often partial.
#fibromyalgia#chronic-pain#mitochondrial-dysfunction - Frameworks· May 31, 2026· 22 min· HCM interpretation
What May Be Driving Chronic Migraine? A Mechanistic Reading of Treatment-Resistant Migraine
Chronic migraine has four upstream drivers: mitochondrial bioenergetic failure, dural mast cell activation, gut-brain axis dysfunction, and hormonal-vasomotor instability. Most treatment-resistant cases (including CGRP antibody non-responders) need the dominant driver addressed at its upstream point.
#chronic-migraine#migraine#cgrp - Fertility· May 30, 2026· 21 min· Mechanistic inference
Why Does Endometriosis Come Back After Surgery? The Gut, Estrobolome, and Bioenergetic Mechanism
Endometriosis recurs because excision removes lesions but not the substrate that selected for them. A mechanistic reading of the gut estrobolome, beta-glucuronidase-driven estrogen recirculation, LPS-driven inflammation, pelvic mast cell infiltration, mitochondrial dysfunction, and iron-driven oxidative damage — and why surgery and hormonal suppression contain the disease but rarely resolve it.
#endometriosis#endometriosis-recurrence#estrobolome - MCAS & Mast Cells· May 26, 2026· 18 min· Mechanistic inference
Why Does MCAS Not Respond to Standard Treatment? The Four Mechanistically Distinct Patterns
Treatment-resistant MCAS may, in a subset of people, be a stratification problem rather than a stabilization problem. At least four candidate mechanistic patterns can contribute to the MCAS phenotype — barrier-driven, neuroimmune/vagal, chemical/toxicant, and clonal/KIT-driven — and they require different upstream interventions. A Host Capacity Model reading of why cromolyn, ketotifen, and the standard stack fail, and what stratification-anchored care looks like.
#mcas#mast-cell-activation-syndrome#treatment-resistant-mcas - MCAS & Mast Cells· May 22, 2026· 3 min· Mechanistic inference
Estrogen, Mast Cells, and Why Your Gut Symptoms Change Across Your Cycle
If you have a chronic gut condition — IBD, IBS, SIBO, MCAS, histamine intolerance, or some overlap of them — you have probably noticed something important: your symptoms are often not random.
#estrogen#mast-cells#histamine - MCAS & Mast Cells· May 14, 2026· 26 min· Mechanistic inference
Histamine Intolerance: Why the DAO Enzyme Story Is Incomplete, and the Real Reason Your Low Histamine Diet Stopped Working
What standard explanations miss about bacterial histamine, the second breakdown enzyme almost nobody discusses, and why mast cell driven reactivity sits on a layer none of these interventions reach.
#histamine#mcas#dao
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