- Frameworks·June 1, 2026· 22 min·HCM interpretationEducational only
What Actually Causes Fibromyalgia? The Mitochondrial, Mast Cell, and Small Fiber Neuropathy Mechanisms Standard Treatment Misses
Fibromyalgia has four upstream drivers: mitochondrial dysfunction, mast cell activation, small fiber neuropathy, and gut-brain axis dysfunction. Lyrica and Cymbalta act on central amplification, not on the peripheral lesions producing the input — which is why response is so often partial.
#fibromyalgia#chronic-pain#mitochondrial-dysfunction#mast-cells#small-fiber-neuropathy#gut-brain-axis#host-capacity-model#lyrica#cymbalta#central-sensitization#post-exertional-malaise#mcas#sibo#oaklander#cd38Read mechanism → - Frameworks·May 31, 2026· 22 min·HCM interpretationEducational only
What Actually Causes Chronic Migraine? A Mechanistic Reading of Treatment-Resistant Migraine
Chronic migraine has four upstream drivers: mitochondrial bioenergetic failure, dural mast cell activation, gut-brain axis dysfunction, and hormonal-vasomotor instability. Most treatment-resistant cases (including CGRP antibody non-responders) need the dominant driver addressed at its upstream point.
#chronic-migraine#migraine#cgrp#vestibular-migraine#hormonal-migraine#mitochondrial-dysfunction#mast-cells#gut-brain-axis#host-capacity-model#mcas#sibo#riboflavin#coq10#perimenopause#treatment-resistant-migraineRead mechanism → - Fertility·May 30, 2026· 21 min·Mechanistic inferenceEducational only
Why Does Endometriosis Come Back After Surgery? The Gut, Estrobolome, and Bioenergetic Mechanism
Endometriosis recurs because excision removes lesions but not the substrate that selected for them. A mechanistic reading of the gut estrobolome, beta-glucuronidase-driven estrogen recirculation, LPS-driven inflammation, pelvic mast cell infiltration, mitochondrial dysfunction, and iron-driven oxidative damage — and why surgery and hormonal suppression contain the disease but rarely resolve it.
#endometriosis#endometriosis-recurrence#estrobolome#beta-glucuronidase#gut-microbiome#host-capacity-model#sibo#mcas#lps#mast-cells#mitochondrial-dysfunction#perimenopause#womens-health#hormonal-healthRead mechanism → - MCAS & Mast Cells·May 26, 2026· 18 min·Mechanistic inferenceEducational only
Why Does MCAS Not Respond to Standard Treatment? The Four Mechanistically Distinct Patterns
Treatment-resistant MCAS is usually a stratification problem, not a stabilization problem. Four mechanistically distinct patterns produce the MCAS phenotype — barrier-driven, neuroimmune/vagal, chemical/toxicant, and clonal/KIT-driven — and they require different upstream interventions. A Host Capacity Model reading of why cromolyn, ketotifen, and the standard stack fail, and what stratification-anchored care looks like.
#mcas#mast-cell-activation-syndrome#treatment-resistant-mcas#mcas-patterns#cromolyn#ketotifen#host-capacity-model#mast-cells#vagal-tone#cholinergic-anti-inflammatory#mold#mycotoxin#kit-d816v#hereditary-alpha-tryptasemiaRead mechanism → - MCAS & Mast Cells·May 14, 2026· 26 min·Mechanistic inferenceEducational only
Histamine Intolerance: Why the DAO Enzyme Story Is Incomplete, and the Real Reason Your Low Histamine Diet Stopped Working
What standard explanations miss about bacterial histamine, the second breakdown enzyme almost nobody discusses, and why mast cell driven reactivity sits on a layer none of these interventions reach.
#histamine#mcas#dao#hnmt#mast-cells#methylation#host-capacity#siboRead mechanism →
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