7 articles
- Host Capacity Model· June 11, 2026· 28 min· Mechanistic inference
Why Dysbiosis, SIBO, Hydrogen Sulfide Intolerance, MCAS, and Long COVID May All Be Downstream of a Single Event
Dysbiosis, SIBO, hydrogen sulfide intolerance, MCAS, and long COVID may all be downstream of one event: the colonocyte losing control of oxygen, butyrate, and its own mitochondria. The Host Capacity Model in full.
#host-capacity-model#colonocyte#butyrate - Frameworks· May 28, 2026· 19 min· HCM interpretation
What May Be Driving POTS? A Mechanistic Reading of Postural Orthostatic Tachycardia Syndrome
POTS may not be one disease. At least four candidate mechanistic pathways — post-viral autonomic ganglion dysfunction, gut-driven vagal dysregulation, connective-tissue-mediated venous pooling, and primary deconditioning — produce the same phenotype. Each needs different intervention. A Host Capacity Model stratification of why standard POTS treatment helps some patients and not others, and how to tell which pathway is dominant in a given case.
#pots#postural-orthostatic-tachycardia-syndrome#dysautonomia - Host Capacity Model· May 14, 2026· 12 min· Mechanistic inference
The Mycotoxin-Mitochondria Trap: Why Standard Detox Fails in Chronic Illness, and How to Escape It
Mycotoxins directly impair mitochondrial function and disrupt the gut oxygen gradient, creating a bioenergetic trap that binders alone cannot break. A Host Capacity Model interpretation of why standard detox protocols fail in SIBO, MCAS, and long COVID, and what the upstream lesion actually requires.
#mycotoxins#mitochondria#colonocyte-bioenergetics - Host Capacity Model· May 14, 2026· 30 min· Mechanistic inference
Why Your Brain Fog Won't Lift: The Six Mechanisms of Cognitive Dysfunction in Chronic Illness, and Why Standard Interventions Keep Failing
What patients with persistent brain fog across long COVID, MCAS, SIBO, perimenopause, and ME/CFS have in common, and where the actual lesion lives.
#brain-fog#long-covid#mcas - Host Capacity Model· May 14, 2026· 32 min· Mechanistic inference
Why Long COVID May Not Resolve: A Mechanistic Reading of Viral Persistence, Mitochondrial Dysfunction, and the Gut–Brain Axis the Standard Model Is Missing
What three years of research actually shows about viral persistence, serotonin depletion, mitochondrial impairment, microclots, and EBV reactivation — and a candidate upstream layer that may tie them together.
#long-covid#mitochondria#viral-persistence - Host Capacity Model· May 14, 2026· 22 min· Mechanistic inference
Why Every Protocol Stops Working After Two Weeks: The Mechanistic Pattern Hiding in Plain Sight in Chronic SIBO, MCAS, and Long COVID
The pattern nobody has named — and what it's actually telling you about your upstream lesion. Why pharmacologically unrelated protocols all plateau on the same two-to-three-week curve, and what that convergence reveals about where your lesion actually lives.
#host-capacity#sibo#mcas - Mitochondria· May 11, 2026· 7 min· Mechanistic inference
Incomplete Autophagy and the Long COVID Lock-In: A Mechanistic Lens
I keep stumbling into the same intersection from different directions. For the last few weeks I’ve been pulling on a thread that started innocently — a question about why some post-COVID patients respond dramatically to extended fasting while others crash. The literature on SA…
#long-covid#autophagy#mitophagy
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