The limits are published alongside the reasoning.
- Evidence tiers
Every article carries an explicit evidence tier, so established biology is never presented as if it were clinical proof.
Read the claim ledger - What this does not prove
Mechanistic pieces are required to state their own limits and the competing explanations that would fit the same data.
See the counterarguments - Published corrections
Where the reasoning has been revised, the revision is recorded rather than quietly edited away.
Review the standards
Pick the sentence that sounds like your situation.
- Why does my SIBO keep coming back?
- Are SIBO breath tests actually reliable?
- Why don't antihistamines settle my symptoms?
- Can I have mast cell activation with normal tryptase?
- Why won't my Long COVID symptoms resolve?
- Why did COVID trigger this in me and not others?
- Why are my labs normal when I feel terrible?
- Why doesn't my stool test match my symptoms?
- Why does every protocol stop working after two weeks?
- Why did butyrate or probiotics make me worse?
- What do bile acids have to do with my gut symptoms?
- Can gut health affect my hormones and egg quality?
Educational mechanistic writing. It does not diagnose, and it does not replace the clinician treating you.
Seven mechanistic threads run through this library.
Recurrent SIBO & breath-test interpretation
14 articles · recurrent SIBO
Mast-cell activation, tryptase & histamine
19 articles · mast cell activation
Long COVID, post-viral gut–immune & POTS
13 articles · Long COVID gut symptoms
Colonocyte bioenergetics, butyrate & oxygen
19 articles · colonocyte bioenergetics
Bile acids, TUDCA & C. difficile ecology
5 articles · bile acid dysfunction
Gut–hormone axis, fertility & estrobolome
3 articles · gut microbiome and fertility
Lab-pattern interpretation
6 articles · lab pattern interpretation
10 articles
- Case Reasoning· August 26, 2026· 18 min· Clinical pattern observation
Long COVID, MCAS, Mold, Heavy Metals, SIBO and Mitochondrial Collapse: A Case That Shows What Happens When We Treat the Target but Forget the Host
A complex case combining Long COVID, ME/CFS physiology, hyperadrenergic POTS, MCAS-type hyperreactivity, recurrent SIBO and methanogen overgrowth, mycotoxin findings, elevated toxic metals and profound mitochondrial respiratory-chain impairment — read as a single host-capacity failure rather than a list of separate targets.
#long-covid#me-cfs#hyperadrenergic-pots - Case Reasoning· August 18, 2026· 24 min· Clinical pattern observation
Long COVID, Candida, and Klebsiella: When the Gut Loses Its Ecological Control
Post-COVID cases repeatedly show loss of ecological control rather than a single pathogen: Candida and Klebsiella expansion as a readout of failed colonization resistance. What that pattern implies for interpretation rather than eradication.
#long-covid#post-viral#candida - Host Capacity Model· June 11, 2026· 28 min· Mechanistic inference
Why Dysbiosis, SIBO, Hydrogen Sulfide Intolerance, MCAS, and Long COVID May All Be Downstream of a Single Event
Dysbiosis, SIBO, hydrogen sulfide intolerance, MCAS, and long COVID may all be downstream of one event: the colonocyte losing control of oxygen, butyrate, and its own mitochondria. The Host Capacity Model in full.
#host-capacity-model#colonocyte#butyrate - Frameworks· May 28, 2026· 19 min· HCM interpretation
What May Be Driving POTS? A Mechanistic Reading of Postural Orthostatic Tachycardia Syndrome
POTS may not be one disease. At least four candidate mechanistic pathways — post-viral autonomic ganglion dysfunction, gut-driven vagal dysregulation, connective-tissue-mediated venous pooling, and primary deconditioning — produce the same phenotype. Each needs different intervention. A Host Capacity Model stratification of why standard POTS treatment helps some patients and not others, and how to tell which pathway is dominant in a given case.
#pots#postural-orthostatic-tachycardia-syndrome#dysautonomia - Host Capacity Model· May 14, 2026· 12 min· Mechanistic inference
The Mycotoxin-Mitochondria Trap: Why Standard Detox Fails in Chronic Illness, and How to Escape It
Mycotoxins directly impair mitochondrial function and disrupt the gut oxygen gradient, creating a bioenergetic trap that binders alone cannot break. A Host Capacity Model interpretation of why standard detox protocols fail in SIBO, MCAS, and long COVID, and what the upstream lesion actually requires.
#mycotoxins#mitochondria#colonocyte-bioenergetics - Host Capacity Model· May 14, 2026· 30 min· Mechanistic inference
Why Your Brain Fog Won't Lift: The Six Mechanisms of Cognitive Dysfunction in Chronic Illness, and Why Standard Interventions Keep Failing
What patients with persistent brain fog across long COVID, MCAS, SIBO, perimenopause, and ME/CFS have in common, and where the actual lesion lives.
#brain-fog#long-covid#mcas - Host Capacity Model· May 14, 2026· 32 min· Mechanistic inference
Why Long COVID May Not Resolve: A Mechanistic Reading of Viral Persistence, Mitochondrial Dysfunction, and the Gut–Brain Axis the Standard Model Is Missing
What three years of research actually shows about viral persistence, serotonin depletion, mitochondrial impairment, microclots, and EBV reactivation — and a candidate upstream layer that may tie them together.
#long-covid#mitochondria#viral-persistence - Host Capacity Model· May 14, 2026· 22 min· Mechanistic inference
Why Every Protocol Stops Working After Two Weeks: The Mechanistic Pattern Hiding in Plain Sight in Chronic SIBO, MCAS, and Long COVID
The pattern nobody has named — and what it's actually telling you about your upstream lesion. Why pharmacologically unrelated protocols all plateau on the same two-to-three-week curve, and what that convergence reveals about where your lesion actually lives.
#host-capacity#sibo#mcas - Mitochondria· May 11, 2026· 7 min· Mechanistic inference
Incomplete Autophagy and the Long COVID Lock-In: A Mechanistic Lens
I keep stumbling into the same intersection from different directions. For the last few weeks I’ve been pulling on a thread that started innocently — a question about why some post-COVID patients respond dramatically to extended fasting while others crash. The literature on SA…
#long-covid#autophagy#mitophagy - MCAS & Mast Cells· April 12, 2026· 20 min· Mechanistic inference
The COVID–Mast Cell Activation Connection: Why Some People Never Fully Recover
Why a subset of people develop persistent food reactivity, flushing, autonomic instability and fatigue after COVID, read through mast-cell biology, genetic variation and post-viral epigenetic change rather than through symptom labels alone.
#covid#long-covid#mast-cell-activation
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