The limits are published alongside the reasoning.
- Evidence tiers
Every article carries an explicit evidence tier, so established biology is never presented as if it were clinical proof.
Read the claim ledger - What this does not prove
Mechanistic pieces are required to state their own limits and the competing explanations that would fit the same data.
See the counterarguments - Published corrections
Where the reasoning has been revised, the revision is recorded rather than quietly edited away.
Review the standards
Pick the sentence that sounds like your situation.
- Why does my SIBO keep coming back?
- Are SIBO breath tests actually reliable?
- Why don't antihistamines settle my symptoms?
- Can I have mast cell activation with normal tryptase?
- Why won't my Long COVID symptoms resolve?
- Why did COVID trigger this in me and not others?
- Why are my labs normal when I feel terrible?
- Why doesn't my stool test match my symptoms?
- Why does every protocol stop working after two weeks?
- Why did butyrate or probiotics make me worse?
- What do bile acids have to do with my gut symptoms?
- Can gut health affect my hormones and egg quality?
Educational mechanistic writing. It does not diagnose, and it does not replace the clinician treating you.
Seven mechanistic threads run through this library.
Recurrent SIBO & breath-test interpretation
13 articles · recurrent SIBO
Mast-cell activation, tryptase & histamine
17 articles · mast cell activation
Long COVID, post-viral gut–immune & POTS
12 articles · Long COVID gut symptoms
Colonocyte bioenergetics, butyrate & oxygen
18 articles · colonocyte bioenergetics
Bile acids, TUDCA & C. difficile ecology
5 articles · bile acid dysfunction
Gut–hormone axis, fertility & estrobolome
3 articles · gut microbiome and fertility
Lab-pattern interpretation
5 articles · lab pattern interpretation
2 articles
- Frameworks· December 19, 2025· 5 min· HCM interpretation
The Alpha-7 Nicotinic Receptor: The Quiet Anti-Inflammatory Switch Inside the Gut Wall
The cholinergic anti-inflammatory pathway is a host-side brake on gut inflammation that bacteria-focused models leave out. What the alpha-7 nicotinic receptor does at the gut wall and why vagal tone matters mechanistically.
#alpha-7-nicotinic-receptor#cholinergic-anti-inflammatory-pathway#vagus - Host Capacity Model· December 19, 2025· 5 min· Mechanistic inference
Your Gut Bacteria Don’t Care What You Eat — They Care About Inflammation
Diet shapes substrate; inflammation and oxygen shape who can live there. Why long-term restrictive diets often fail to change the ecology they were meant to clarify.
#diet#low-fodmap#inflammation
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