21 articles · showing 12
- Case Reasoning· August 3, 2026· 12 min· Clinical pattern observation
The Microbial Metabolites That May Be Rewiring the Brain: The Hidden Link Between SIBO, IBS, MCAS, Autism, ADHD, Glutamate, and Catecholamine Dysfunction
HPHPA, hydrogen sulfide, D-lactate and ammonia are microbial metabolites that may pressure catecholamine regulation through dopamine β-hydroxylase, COMT and mitochondrial ATP. A case-anchored look at the hidden link between SIBO, IBS, MCAS, POTS, ADHD-like symptoms and autism-spectrum features — a metabolite-driven mechanism rather than a purely compositional dysbiosis.
#hphpa#clostridia#dopamine-beta-hydroxylase - SIBO· August 2, 2026· 13 min· Mechanistic inference
Beyond Bacteria: Is Bile Acid Ecology One of the Missing Pieces in Chronic SIBO?
Over the last several years, I have spent countless hours studying chronic gut dysfunction while working with individuals suffering from small intestinal bacterial overgrowth (SIBO), hydrogen sulfide overgrowth, mast cell activation syndrome (MCAS)-related gastrointestinal sym…
#bile-acids#sibo#bile-acid-malabsorption - Frameworks· July 30, 2026· 11 min· HCM interpretation
SIBO, MCAS, POTS and Food Intolerance May Be One Self-Sustaining System
For years, SIBO, MCAS, POTS, dysautonomia, food intolerance, chronic fatigue, neurological symptoms, and mitochondrial dysfunction have been treated as separate diagnoses.
#sibo#mcas#pots - Case Reasoning· July 29, 2026· 32 min· Clinical pattern observation
What a Two-Decade Steroid-Dependent IBD Case Revealed About Redox Collapse, Malabsorption, Microbial Instability, and Host Capacity
A man in his forties with two decades of steroid-dependent inflammatory bowel disease was taking four grams of vitamin C daily — and his ascorbate marker sat near the bottom of the range. That contradiction opened a full mechanistic case analysis of redox collapse, fat malabsorption, microbial instability, and host capacity.
#case-study#ibd#crohns - MCAS & Mast Cells· July 17, 2026· 28 min· Mechanistic inference
Rethinking Chronic Dysbiosis, Mast Cell Activation, and the Failure of Intestinal Ecological Control
Why the microbiome may remain unstable until the intestinal epithelium regains the capacity to metabolize microbial products, consume oxygen, regulate inflammation, and rebuild itself
#dysbiosis#mast-cells#mcas - Host Capacity Model· June 11, 2026· 28 min· Mechanistic inference
Why Dysbiosis, SIBO, Hydrogen Sulfide Intolerance, MCAS, and Long COVID May All Be Downstream of a Single Event
Dysbiosis, SIBO, hydrogen sulfide intolerance, MCAS, and long COVID may all be downstream of one event: the colonocyte losing control of oxygen, butyrate, and its own mitochondria. The Host Capacity Model in full.
#host-capacity-model#colonocyte#butyrate - MCAS & Mast Cells· June 9, 2026· 13 min· Mechanistic inference
Why Mast Cell Activation May Be the Last Domino, Not the First — A Systems-Biology Reframe of MCAS
For decades, the mast cell has carried a reputation it may not fully deserve. We learned it as the cell of allergy: the histamine grenade, the hive, the wheeze, the anaphylactic emergency. In that framing, Mast Cell Activation Syndrome (MCAS) becomes a straightforward story —…
#mcas#mast-cells#systems-biology - Frameworks· June 3, 2026· 3 min· HCM interpretation
The Gut Biomarker Almost No One Tests
One of the most consistent patterns I keep finding in complex gut cases is something that rarely gets discussed: low Secretory IgA (sIgA).
#biomarkers#stool-testing#lab-interpretation - SIBO· June 1, 2026· 22 min· Mechanistic inference
What May Be Driving GERD and Acid Reflux? Why Long-Term PPI Use Often Makes It Worse
GERD is rarely too much acid. It's lower esophageal sphincter dysfunction with pressure from SIBO, gastroparesis, vagal compromise, and bioenergetic failure. Long-term PPI use often perpetuates the underlying disease through rebound hypersecretion and SIBO induction.
#gerd#acid-reflux#ppi - Frameworks· June 1, 2026· 23 min· HCM interpretation
What May Be Driving PCOS? A Mechanistic Reading of Polycystic Ovary Syndrome
PCOS is not primarily ovarian. Gut dysbiosis, insulin resistance, estrobolome dysfunction, mitochondrial failure, and the CD38-NAD+-SIRT3 cascade drive the disease. Birth control and metformin contain the readout while the upstream lesions persist.
#pcos#polycystic-ovary-syndrome#insulin-resistance - Frameworks· June 1, 2026· 22 min· HCM interpretation
What May Be Driving Fibromyalgia? The Mitochondrial, Mast Cell, and Small Fiber Neuropathy Mechanisms Standard Treatment Misses
Fibromyalgia has four upstream drivers: mitochondrial dysfunction, mast cell activation, small fiber neuropathy, and gut-brain axis dysfunction. Lyrica and Cymbalta act on central amplification, not on the peripheral lesions producing the input — which is why response is so often partial.
#fibromyalgia#chronic-pain#mitochondrial-dysfunction - Frameworks· May 31, 2026· 22 min· HCM interpretation
What May Be Driving Chronic Migraine? A Mechanistic Reading of Treatment-Resistant Migraine
Chronic migraine has four upstream drivers: mitochondrial bioenergetic failure, dural mast cell activation, gut-brain axis dysfunction, and hormonal-vasomotor instability. Most treatment-resistant cases (including CGRP antibody non-responders) need the dominant driver addressed at its upstream point.
#chronic-migraine#migraine#cgrp
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