The limits are published alongside the reasoning.
- Evidence tiers
Every article carries an explicit evidence tier, so established biology is never presented as if it were clinical proof.
Read the claim ledger - What this does not prove
Mechanistic pieces are required to state their own limits and the competing explanations that would fit the same data.
See the counterarguments - Published corrections
Where the reasoning has been revised, the revision is recorded rather than quietly edited away.
Review the standards
Pick the sentence that sounds like your situation.
- Why does my SIBO keep coming back?
- Are SIBO breath tests actually reliable?
- Why don't antihistamines settle my symptoms?
- Can I have mast cell activation with normal tryptase?
- Why won't my Long COVID symptoms resolve?
- Why did COVID trigger this in me and not others?
- Why are my labs normal when I feel terrible?
- Why doesn't my stool test match my symptoms?
- Why does every protocol stop working after two weeks?
- Why did butyrate or probiotics make me worse?
- What do bile acids have to do with my gut symptoms?
- Can gut health affect my hormones and egg quality?
Educational mechanistic writing. It does not diagnose, and it does not replace the clinician treating you.
Seven mechanistic threads run through this library.
Recurrent SIBO & breath-test interpretation
16 articles · recurrent SIBO
Mast-cell activation, tryptase & histamine
23 articles · mast cell activation
Long COVID, post-viral gut–immune & POTS
18 articles · Long COVID gut symptoms
Colonocyte bioenergetics, butyrate & oxygen
20 articles · colonocyte bioenergetics
Bile acids, TUDCA & C. difficile ecology
7 articles · bile acid dysfunction
Gut–hormone axis, fertility & estrobolome
8 articles · gut microbiome and fertility
Lab-pattern interpretation
6 articles · lab pattern interpretation
14 articles · showing 12
- SIBO· October 25, 2026· 25 min· Mechanistic inference
What If We’re Missing Something About ADHD and Autism? The Biology That Begins Before Birth
Maternal Immune Activation, GABA Signaling, Epigenetics, the Gut Microbiome, and the Early Development of a Brain Built for Survival
#bile-acids#estrogen#progesterone - SIBO· October 24, 2026· 13 min· Mechanistic inference
The Bile Acid–Estrogen Connection: A Missing Piece in Women’s Hormonal and Gut Health
One of the most interesting patterns I’ve been investigating through my work with women experiencing hormonal changes, gastrointestinal dysfunction, and complex chronic illness involves something that often receives very little attention
#histamine#mast-cells#bile-acids - MCAS & Mast Cells· October 23, 2026· 28 min· Mechanistic inference
Why Progesterone Calms One Woman but Sends Another Into Panic: The Hidden Biology of Hormonal Sensitivity
Why women can experience severe anxiety, insomnia, panic, and emotional changes despite normal hormone tests—and what allopregnanolone, GABA receptors, childhood trauma, neuroinflammation
#hormone#gut#progesterone - SIBO· October 22, 2026· 31 min· Mechanistic inference
Facial Flushing, Racing Heart, Gut Pain, and Crashing After Meals: Could Excess Gut Serotonin Be Driving Mast Cell Activation?
The hidden connection between serotonin overload, Prevotella copri, impaired serotonin clearance, and the gut–immune–nervous system.
#mast-cell-activation#gut-health#sertonin - MCAS & Mast Cells· October 21, 2026· 7 min· Mechanistic inference
Why Progesterone Can Calm One Woman and Make Another Worse: The Overlooked Connection Between Trauma, Allopregnanolone, Mast Cells, and Women's Brain Health
Something I hear frequently from women I work with is the frustration of receiving a diagnosis, being prescribed a hormone or medication, and then experiencing symptoms that nobody seems able to explain.
#histamine#mast-cells#estrogen - MCAS & Mast Cells· October 20, 2026· 28 min· Mechanistic inference
Immunoadsorption (IA): The German Therapy That Removes Autoantibodies From the Blood — Could It Change the Future of Autoimmune Disease?
Over the past several months, I have been spending considerable time investigating a treatment called immunoadsorption, commonly abbreviated as IA.
#mcas#long-covid#dysautonomia - SIBO· October 8, 2026· 33 min· Mechanistic inference
Bile Acids, GLP-1, and the Overlooked Connection Between the Microbiome and Metabolic Health
I get asked about GLP-1 medications quite frequently, particularly semaglutide and tirzepatide, and whether their benefits extend beyond weight loss and blood glucose regulation.
#long-covid#dysautonomia#bile-acids - SIBO· September 30, 2026· 29 min· Mechanistic inference
10 Things I Have Learned About Long COVID From Client Data and Research
I have not written in depth about Long COVID for a while, although it has continued to appear repeatedly in the complex cases I analyze.
#long-covid#sibo#pots - Host Capacity Model· September 27, 2026· 29 min· Mechanistic inference
FKBP5, Cortisol, Childhood Environment, Epigenetic Programming, and the Developmental Biology Behind ADHD and Other Neuropsychiatric Phenotypes
One of the areas I have been working on is trying to understand what happens when genetics, childhood environment, stress physiology, and neurodevelopment are no longer treated as separate subjects.
#ocd#adhd#bile-acids - SIBO· September 23, 2026· 25 min· Mechanistic inference
10 Things I Learned About SIBO That Explain Why It Keeps Coming Back
The more I study SIBO and work through people who have been dealing with it for years, the less I think the most important question is simply what will kill the bacteria.
#sibo#bile-acids#hormones - SIBO· September 17, 2026· 15 min· Mechanistic inference
The Mold Is Only Half the Story: Why the Host Determines the Toxicity
I have been working through a particularly complex mold-related case, and the deeper I went into the client’s history, laboratory testing, genetics, mitochondrial findings, gastrointestinal findings, supplement exposures, and older
#mold#bile-acids#hormones - MCAS & Mast Cells· September 16, 2026· 10 min· Mechanistic inference
10 Things I Learned About Mast Cells That Changed How I Understand MCAS
The more I study mast cells and work through complex cases, the less useful it becomes to think of them simply as “histamine cells.” Histamine is important, but mast cells are much more sophisticated than that.
#mcas#histamine#mast-cells
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