The limits are published alongside the reasoning.
- Evidence tiers
Every article carries an explicit evidence tier, so established biology is never presented as if it were clinical proof.
Read the claim ledger - What this does not prove
Mechanistic pieces are required to state their own limits and the competing explanations that would fit the same data.
See the counterarguments - Published corrections
Where the reasoning has been revised, the revision is recorded rather than quietly edited away.
Review the standards
Pick the sentence that sounds like your situation.
- Why does my SIBO keep coming back?
- Are SIBO breath tests actually reliable?
- Why don't antihistamines settle my symptoms?
- Can I have mast cell activation with normal tryptase?
- Why won't my Long COVID symptoms resolve?
- Why did COVID trigger this in me and not others?
- Why are my labs normal when I feel terrible?
- Why doesn't my stool test match my symptoms?
- Why does every protocol stop working after two weeks?
- Why did butyrate or probiotics make me worse?
- What do bile acids have to do with my gut symptoms?
- Can gut health affect my hormones and egg quality?
Educational mechanistic writing. It does not diagnose, and it does not replace the clinician treating you.
Seven mechanistic threads run through this library.
Recurrent SIBO & breath-test interpretation
14 articles · recurrent SIBO
Mast-cell activation, tryptase & histamine
19 articles · mast cell activation
Long COVID, post-viral gut–immune & POTS
13 articles · Long COVID gut symptoms
Colonocyte bioenergetics, butyrate & oxygen
19 articles · colonocyte bioenergetics
Bile acids, TUDCA & C. difficile ecology
5 articles · bile acid dysfunction
Gut–hormone axis, fertility & estrobolome
3 articles · gut microbiome and fertility
Lab-pattern interpretation
6 articles · lab pattern interpretation
5 articles
- Frameworks· June 1, 2026· 22 min· HCM interpretation
What May Be Driving Fibromyalgia? The Mitochondrial, Mast Cell, and Small Fiber Neuropathy Mechanisms Standard Treatment Misses
Fibromyalgia has four upstream drivers: mitochondrial dysfunction, mast cell activation, small fiber neuropathy, and gut-brain axis dysfunction. Lyrica and Cymbalta act on central amplification, not on the peripheral lesions producing the input — which is why response is so often partial.
#fibromyalgia#chronic-pain#mitochondrial-dysfunction - Frameworks· May 31, 2026· 22 min· HCM interpretation
What May Be Driving Chronic Migraine? A Mechanistic Reading of Treatment-Resistant Migraine
Chronic migraine has four upstream drivers: mitochondrial bioenergetic failure, dural mast cell activation, gut-brain axis dysfunction, and hormonal-vasomotor instability. Most treatment-resistant cases (including CGRP antibody non-responders) need the dominant driver addressed at its upstream point.
#chronic-migraine#migraine#cgrp - Frameworks· May 31, 2026· 3 min· HCM interpretation
The Gut Is Wiring the Brain: The Biomarker Pattern I Keep Finding in Autism and ADHD
Over the last several years, while reviewing complex pediatric cases involving autism spectrum disorder, ADHD, developmental regression, sensory dysfunction, hyperactivity, and mixed neurodevelopmental presentations, I have repeatedly observed a similar biological pattern emer…
#gut-brain-axis#adhd#autism - SIBO· April 11, 2026· 8 min· Mechanistic inference
The Tryptophan Trap: What Antidepressants Do to a SIBO Gut
What serotonergic medication does inside a small intestine that is already fermenting: tryptophan partitioning, motility signalling and the kynurenine shift. A mechanistic reading, not medication advice.
#tryptophan#ssri#serotonin - SIBO· March 30, 2026· 11 min· Mechanistic inference
Hydrogen Sulfide, Serotonin Control, and Why Gut Motility Becomes Unstable
Serotonin in the gut is a control signal, not a mood molecule. How excess microbial hydrogen sulfide can disturb serotonin handling and make motility unstable in both directions.
#hydrogen-sulfide#serotonin#5-ht
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