3 articles
- Frameworks· June 1, 2026· 22 min· HCM interpretation
What May Be Driving Fibromyalgia? The Mitochondrial, Mast Cell, and Small Fiber Neuropathy Mechanisms Standard Treatment Misses
Fibromyalgia has four upstream drivers: mitochondrial dysfunction, mast cell activation, small fiber neuropathy, and gut-brain axis dysfunction. Lyrica and Cymbalta act on central amplification, not on the peripheral lesions producing the input — which is why response is so often partial.
#fibromyalgia#chronic-pain#mitochondrial-dysfunction - Frameworks· May 31, 2026· 22 min· HCM interpretation
What May Be Driving Chronic Migraine? A Mechanistic Reading of Treatment-Resistant Migraine
Chronic migraine has four upstream drivers: mitochondrial bioenergetic failure, dural mast cell activation, gut-brain axis dysfunction, and hormonal-vasomotor instability. Most treatment-resistant cases (including CGRP antibody non-responders) need the dominant driver addressed at its upstream point.
#chronic-migraine#migraine#cgrp - Frameworks· May 31, 2026· 3 min· HCM interpretation
The Gut Is Wiring the Brain: The Biomarker Pattern I Keep Finding in Autism and ADHD
Over the last several years, while reviewing complex pediatric cases involving autism spectrum disorder, ADHD, developmental regression, sensory dysfunction, hyperactivity, and mixed neurodevelopmental presentations, I have repeatedly observed a similar biological pattern emer…
#gut-brain-axis#adhd#autism
Receive new articles.
New mechanistic essays delivered when published. Compatible with the existing Substack readership at @mohammedattallah.