3 articles
- Frameworks· June 1, 2026· 23 min· HCM interpretation
What May Be Driving PCOS? A Mechanistic Reading of Polycystic Ovary Syndrome
PCOS is not primarily ovarian. Gut dysbiosis, insulin resistance, estrobolome dysfunction, mitochondrial failure, and the CD38-NAD+-SIRT3 cascade drive the disease. Birth control and metformin contain the readout while the upstream lesions persist.
#pcos#polycystic-ovary-syndrome#insulin-resistance - Fertility· May 8, 2026· 4 min· Literature-supported mechanism
How Dysbiosis Disrupts Hormonal Health, Ovulation, and Egg Quality From the Inside Out
The fertility conversation has become overwhelmingly hormone-centric, but one of the most important mechanistic layers is still being underappreciated: the inflammatory dialogue between the gut microbiome and the ovary itself.
#butyrate#dysbiosis#lps - Fertility· April 19, 2026· 15 min· Mechanistic inference
Microplastics and Forever Chemicals: Why Your Body Can't Detox Them — and What It Actually Needs
The biology behind the Netflix panic and why generic "detox" protocols keep failing the people who need them most.
#barrier#fertility
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New mechanistic essays delivered when published. Compatible with the existing Substack readership at @mohammedattallah.