- Frameworks·June 1, 2026· 23 min·HCM interpretationEducational only
What Actually Causes PCOS? A Mechanistic Reading of Polycystic Ovary Syndrome
PCOS is not primarily ovarian. Gut dysbiosis, insulin resistance, estrobolome dysfunction, mitochondrial failure, and the CD38-NAD+-SIRT3 cascade drive the disease. Birth control and metformin contain the readout while the upstream lesions persist.
#pcos#polycystic-ovary-syndrome#insulin-resistance#gut-dysbiosis#dogma-hypothesis#host-capacity-model#metformin#berberine#inositol#lean-pcos#hashimotos#estrobolome#womens-health#fertility#hyperandrogenismRead mechanism → - Fertility·May 8, 2026· 4 min·Literature-supported mechanismEducational only
How Dysbiosis Disrupts Hormonal Health, Ovulation, and Egg Quality From the Inside Out
The fertility conversation has become overwhelmingly hormone-centric, but one of the most important mechanistic layers is still being underappreciated: the inflammatory dialogue between the gut microbiome and the ovary itself.
#butyrate#dysbiosis#lps#barrier#fertilityRead mechanism → - Fertility·April 19, 2026· 15 min·Mechanistic inferenceEducational only
Microplastics and Forever Chemicals: Why Your Body Can't Detox Them — and What It Actually Needs
The biology behind the Netflix panic and why generic "detox" protocols keep failing the people who need them most.
#barrier#fertilityRead mechanism →
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New mechanistic essays delivered when published. Compatible with the existing Substack readership at @mohammedattallah.