15 articles · showing 12
- Case Reasoning· July 29, 2026· 32 min· Clinical pattern observation
What a Two-Decade Steroid-Dependent IBD Case Revealed About Redox Collapse, Malabsorption, Microbial Instability, and Host Capacity
A man in his forties with two decades of steroid-dependent inflammatory bowel disease was taking four grams of vitamin C daily — and his ascorbate marker sat near the bottom of the range. That contradiction opened a full mechanistic case analysis of redox collapse, fat malabsorption, microbial instability, and host capacity.
#case-study#ibd#crohns - MCAS & Mast Cells· July 17, 2026· 28 min· Mechanistic inference
Rethinking Chronic Dysbiosis, Mast Cell Activation, and the Failure of Intestinal Ecological Control
Why the microbiome may remain unstable until the intestinal epithelium regains the capacity to metabolize microbial products, consume oxygen, regulate inflammation, and rebuild itself
#dysbiosis#mast-cells#mcas - Host Capacity Model· June 11, 2026· 28 min· Mechanistic inference
Why Dysbiosis, SIBO, Hydrogen Sulfide Intolerance, MCAS, and Long COVID May All Be Downstream of a Single Event
Dysbiosis, SIBO, hydrogen sulfide intolerance, MCAS, and long COVID may all be downstream of one event: the colonocyte losing control of oxygen, butyrate, and its own mitochondria. The Host Capacity Model in full.
#host-capacity-model#colonocyte#butyrate - MCAS & Mast Cells· June 9, 2026· 13 min· Mechanistic inference
Why Mast Cell Activation May Be the Last Domino, Not the First — A Systems-Biology Reframe of MCAS
For decades, the mast cell has carried a reputation it may not fully deserve. We learned it as the cell of allergy: the histamine grenade, the hive, the wheeze, the anaphylactic emergency. In that framing, Mast Cell Activation Syndrome (MCAS) becomes a straightforward story —…
#mcas#mast-cells#systems-biology - SIBO· May 25, 2026· 16 min· Mechanistic inference
Why Does SIBO Keep Coming Back After Treatment?
Recurrent SIBO may represent an equilibrium state of an unaddressed host substrate failure. Antimicrobials reduce overgrowth without restoring the colonocyte bioenergetic capacity that defines which microbes can dominate. A Host Capacity Model reading of the recurrence cycle, the SLC5A8 / Fe-S / CD38-NAD+-SIRT3 mechanisms behind it, and what an HCM-anchored approach actually looks like.
#sibo#recurrent-sibo#host-capacity-model - Host Capacity Model· May 21, 2026· 23 min· Mechanistic inference
Why Probiotics Make You Sicker, Not Better: The Six Mechanisms Driving Probiotic Failure in MCAS, SIBO, Histamine Intolerance, and Long COVID, and Why The Field Has Been Asking The Wrong Question
What the research actually shows about why patients with chronic gut dysfunction react badly to the most widely recommended supplement in functional medicine, and where the actual lesion lives.
#probiotics#histamine#d-lactate - Host Capacity Model· May 14, 2026· 25 min· Mechanistic inference
Why Your Stool Test Doesn't Match Your Symptoms: The Mechanistic Limits of GI-MAP, BiomeFx, and Comprehensive Stool Analysis
What GI-MAP, BiomeFx, Genova, and comprehensive stool panels actually measure, what they cannot, and how to read your own gut when the report falls short.
#stool-testing#gi-map#biomefx - Fertility· May 8, 2026· 4 min· Literature-supported mechanism
How Dysbiosis Disrupts Hormonal Health, Ovulation, and Egg Quality From the Inside Out
The fertility conversation has become overwhelmingly hormone-centric, but one of the most important mechanistic layers is still being underappreciated: the inflammatory dialogue between the gut microbiome and the ovary itself.
#butyrate#dysbiosis#lps - SIBO· May 2, 2026· 20 min· Literature-supported mechanism
The Hidden Driver of SIBO and Chronic Gut Dysfunction: Bile Acid Malabsorption, Dysbiosis, and the Mitochondrial Cascade
The Overlooked Mechanism That Defines Treatment Failure
#sibo#mitochondri#bile - SIBO· April 28, 2026· 11 min· Mechanistic inference
The Single Molecule Driving Both Your SIBO and Your MCAS (And Why Nothing Has Worked)
If you have IBS, and MCAS, and maybe SIBO and you ve been told these are three separate problems that just happen to co-occur in unlucky people like you I want to show you something.
#sibo#mcas#dysbiosis - Case Reasoning· April 27, 2026· 21 min· Clinical pattern observation
The Same Barrier Collapses Everywhere: Why Dysbiosis Causes ADHD, Brain Fog, Anxiety, Depression, and Chronic Fatigue Simultaneously—And Why You Can't Treat Them Separately The Discovery That Changes
I ve spent months in the primary literature exploring a phenomenon that mainstream medicine completely misses: the same physical structures that seal your gut are the identical structures that seal your brain, and dysbiosis doesn t break just one of them it breaks both simultaneo
#dysbiosis#barrier - Mitochondria· April 25, 2026· 6 min· Mechanistic inference
The Iron-Sulfur Cluster Crisis: Why Your Mitochondria Can't Recover (And Why Practitioners Don't Talk About It)
Your SIBO keeps coming back. Your IBS flares without warning. Your energy tanked despite "fixing" your microbiome. Most practitioners will blame the bacteria, the metabolites
#mitochondri#dysbiosis#colonocyte
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