The limits are published alongside the reasoning.
- Evidence tiers
Every article carries an explicit evidence tier, so established biology is never presented as if it were clinical proof.
Read the claim ledger - What this does not prove
Mechanistic pieces are required to state their own limits and the competing explanations that would fit the same data.
See the counterarguments - Published corrections
Where the reasoning has been revised, the revision is recorded rather than quietly edited away.
Review the standards
Pick the sentence that sounds like your situation.
- Why does my SIBO keep coming back?
- Are SIBO breath tests actually reliable?
- Why don't antihistamines settle my symptoms?
- Can I have mast cell activation with normal tryptase?
- Why won't my Long COVID symptoms resolve?
- Why did COVID trigger this in me and not others?
- Why are my labs normal when I feel terrible?
- Why doesn't my stool test match my symptoms?
- Why does every protocol stop working after two weeks?
- Why did butyrate or probiotics make me worse?
- What do bile acids have to do with my gut symptoms?
- Can gut health affect my hormones and egg quality?
Educational mechanistic writing. It does not diagnose, and it does not replace the clinician treating you.
Seven mechanistic threads run through this library.
Recurrent SIBO & breath-test interpretation
16 articles · recurrent SIBO
Mast-cell activation, tryptase & histamine
23 articles · mast cell activation
Long COVID, post-viral gut–immune & POTS
18 articles · Long COVID gut symptoms
Colonocyte bioenergetics, butyrate & oxygen
20 articles · colonocyte bioenergetics
Bile acids, TUDCA & C. difficile ecology
7 articles · bile acid dysfunction
Gut–hormone axis, fertility & estrobolome
8 articles · gut microbiome and fertility
Lab-pattern interpretation
6 articles · lab pattern interpretation
11 articles
- SIBO· October 22, 2026· 31 min· Mechanistic inference
Facial Flushing, Racing Heart, Gut Pain, and Crashing After Meals: Could Excess Gut Serotonin Be Driving Mast Cell Activation?
The hidden connection between serotonin overload, Prevotella copri, impaired serotonin clearance, and the gut–immune–nervous system.
#mast-cell-activation#gut-health#sertonin - MCAS & Mast Cells· October 20, 2026· 28 min· Mechanistic inference
Immunoadsorption (IA): The German Therapy That Removes Autoantibodies From the Blood — Could It Change the Future of Autoimmune Disease?
Over the past several months, I have been spending considerable time investigating a treatment called immunoadsorption, commonly abbreviated as IA.
#mcas#long-covid#dysautonomia - Mitochondria· October 19, 2026· 18 min· Mechanistic inference
When the Brain Can No Longer Clear Its Own Signals: Anti-Tubulin Antibodies, Glutamate, GABA, and the Hidden Neurobiology of Long COVID
There is something I have been paying closer attention to while working through complex long COVID and post-infectious cases, particularly in people experiencing neurological symptoms that are difficult to explain through conventional
#long-covid#dysautonomia#mitochondria - SIBO· October 8, 2026· 33 min· Mechanistic inference
Bile Acids, GLP-1, and the Overlooked Connection Between the Microbiome and Metabolic Health
I get asked about GLP-1 medications quite frequently, particularly semaglutide and tirzepatide, and whether their benefits extend beyond weight loss and blood glucose regulation.
#long-covid#dysautonomia#bile-acids - SIBO· September 30, 2026· 29 min· Mechanistic inference
10 Things I Have Learned About Long COVID From Client Data and Research
I have not written in depth about Long COVID for a while, although it has continued to appear repeatedly in the complex cases I analyze.
#long-covid#sibo#pots - SIBO· September 7, 2026· 35 min· Mechanistic inference
The Histamine Problem Nobody Explains: Why Some People Suddenly Start Reacting to Everything
The more I research histamine, and the more I work through complex cases involving MCAS, POTS, dysautonomia, SIBO, food reactions, gastrointestinal dysfunction, hormonal changes, medication sensitivities, flushing, itching, headaches
#sibo#mcas#histamine - SIBO· September 5, 2026· 6 min· Mechanistic inference
The Rifaximin Trap: Killing SIBO Without Fixing Why It Keeps Coming Back
The more I research SIBO and work through complex gastrointestinal cases, the more I think we are asking the wrong question.
#sibo#pots#dysautonomia - SIBO· September 3, 2026· 17 min· Mechanistic inference
Mold Toxicity Is More Than Exposure: The Mitochondria–Gut–Immune Cascade Behind Chronic Illness
From my research into mold, mycotoxins, mitochondrial physiology, gut ecology, immune signaling and host genetics, and from the patterns I continue to examine while working through complex gastrointestinal, autonomic, neurological
#microbime#mast-cell-activation#mold - Case Reasoning· August 21, 2026· 13 min· Clinical pattern observation
The Gut–Catecholamine Connection in POTS: How HPHPA May Disrupt Norepinephrine, Vascular Tone, and Methylation
A mechanistic reading of why a microbial aromatic metabolite (HPHPA) may sit upstream of catecholamine handling, vascular tone and methylation load in POTS and dysautonomia. Hypothesis-generating, anchored in organic-acid and microbiome patterns seen in complex cases.
#hphpa#pots#dysautonomia - Frameworks· May 28, 2026· 19 min· HCM interpretation
What May Be Driving POTS? A Mechanistic Reading of Postural Orthostatic Tachycardia Syndrome
POTS may not be one disease. At least four candidate mechanistic pathways — post-viral autonomic ganglion dysfunction, gut-driven vagal dysregulation, connective-tissue-mediated venous pooling, and primary deconditioning — produce the same phenotype. Each needs different intervention. A Host Capacity Model stratification of why standard POTS treatment helps some patients and not others, and how to tell which pathway is dominant in a given case.
#pots#postural-orthostatic-tachycardia-syndrome#dysautonomia - MCAS & Mast Cells· April 12, 2026· 20 min· Mechanistic inference
The COVID–Mast Cell Activation Connection: Why Some People Never Fully Recover
Why a subset of people develop persistent food reactivity, flushing, autonomic instability and fatigue after COVID, read through mast-cell biology, genetic variation and post-viral epigenetic change rather than through symptom labels alone.
#covid#long-covid#mast-cell-activation
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