The limits are published alongside the reasoning.
- Evidence tiers
Every article carries an explicit evidence tier, so established biology is never presented as if it were clinical proof.
Read the claim ledger - What this does not prove
Mechanistic pieces are required to state their own limits and the competing explanations that would fit the same data.
See the counterarguments - Published corrections
Where the reasoning has been revised, the revision is recorded rather than quietly edited away.
Review the standards
Pick the sentence that sounds like your situation.
- Why does my SIBO keep coming back?
- Are SIBO breath tests actually reliable?
- Why don't antihistamines settle my symptoms?
- Can I have mast cell activation with normal tryptase?
- Why won't my Long COVID symptoms resolve?
- Why did COVID trigger this in me and not others?
- Why are my labs normal when I feel terrible?
- Why doesn't my stool test match my symptoms?
- Why does every protocol stop working after two weeks?
- Why did butyrate or probiotics make me worse?
- What do bile acids have to do with my gut symptoms?
- Can gut health affect my hormones and egg quality?
Educational mechanistic writing. It does not diagnose, and it does not replace the clinician treating you.
Seven mechanistic threads run through this library.
Recurrent SIBO & breath-test interpretation
16 articles · recurrent SIBO
Mast-cell activation, tryptase & histamine
23 articles · mast cell activation
Long COVID, post-viral gut–immune & POTS
18 articles · Long COVID gut symptoms
Colonocyte bioenergetics, butyrate & oxygen
20 articles · colonocyte bioenergetics
Bile acids, TUDCA & C. difficile ecology
7 articles · bile acid dysfunction
Gut–hormone axis, fertility & estrobolome
8 articles · gut microbiome and fertility
Lab-pattern interpretation
6 articles · lab pattern interpretation
6 articles
- SIBO· October 25, 2026· 25 min· Mechanistic inference
What If We’re Missing Something About ADHD and Autism? The Biology That Begins Before Birth
Maternal Immune Activation, GABA Signaling, Epigenetics, the Gut Microbiome, and the Early Development of a Brain Built for Survival
#bile-acids#estrogen#progesterone - MCAS & Mast Cells· October 23, 2026· 28 min· Mechanistic inference
Why Progesterone Calms One Woman but Sends Another Into Panic: The Hidden Biology of Hormonal Sensitivity
Why women can experience severe anxiety, insomnia, panic, and emotional changes despite normal hormone tests—and what allopregnanolone, GABA receptors, childhood trauma, neuroinflammation
#hormone#gut#progesterone - MCAS & Mast Cells· October 21, 2026· 7 min· Mechanistic inference
Why Progesterone Can Calm One Woman and Make Another Worse: The Overlooked Connection Between Trauma, Allopregnanolone, Mast Cells, and Women's Brain Health
Something I hear frequently from women I work with is the frustration of receiving a diagnosis, being prescribed a hormone or medication, and then experiencing symptoms that nobody seems able to explain.
#histamine#mast-cells#estrogen - Host Capacity Model· September 27, 2026· 29 min· Mechanistic inference
FKBP5, Cortisol, Childhood Environment, Epigenetic Programming, and the Developmental Biology Behind ADHD and Other Neuropsychiatric Phenotypes
One of the areas I have been working on is trying to understand what happens when genetics, childhood environment, stress physiology, and neurodevelopment are no longer treated as separate subjects.
#ocd#adhd#bile-acids - MCAS & Mast Cells· September 16, 2026· 10 min· Mechanistic inference
10 Things I Learned About Mast Cells That Changed How I Understand MCAS
The more I study mast cells and work through complex cases, the less useful it becomes to think of them simply as “histamine cells.” Histamine is important, but mast cells are much more sophisticated than that.
#mcas#histamine#mast-cells - Host Capacity Model· September 11, 2026· 24 min· Mechanistic inference
ADHD Is Not Simply “Low Dopamine”: What Studying the Biology and My Own Genetics Has Taught Me
I have been looking into ADHD biology for a very long time, particularly the genetic and molecular side of it, and because I have ADHD myself and have been formally diagnosed with it, this subject has always been personal to me as much as
#adhd#serotonin#dopamine
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