4 articles
- Frameworks· May 29, 2026· 21 min· HCM interpretation
What May Be Driving IBD? A Mechanistic Reading of Crohn's Disease and Ulcerative Colitis
IBD is not a single autoimmune disease. At the cellular level both Crohn's and ulcerative colitis are dominated by colonocyte bioenergetic failure — loss of butyrate oxidation, collapse of the gut oxygen gradient, and the inflammatory cascade that follows. A mechanistic reading anchored in primary research from Roediger 1990 onward, and why standard immunosuppression contains the response but does not restore the upstream lesion.
#ibd#crohns-disease#ulcerative-colitis - SIBO· May 25, 2026· 16 min· Mechanistic inference
Why Does SIBO Keep Coming Back After Treatment?
Recurrent SIBO may represent an equilibrium state of an unaddressed host substrate failure. Antimicrobials reduce overgrowth without restoring the colonocyte bioenergetic capacity that defines which microbes can dominate. A Host Capacity Model reading of the recurrence cycle, the SLC5A8 / Fe-S / CD38-NAD+-SIRT3 mechanisms behind it, and what an HCM-anchored approach actually looks like.
#sibo#recurrent-sibo#host-capacity-model - Host Capacity Model· May 14, 2026· 12 min· Mechanistic inference
The Mycotoxin-Mitochondria Trap: Why Standard Detox Fails in Chronic Illness, and How to Escape It
Mycotoxins directly impair mitochondrial function and disrupt the gut oxygen gradient, creating a bioenergetic trap that binders alone cannot break. A Host Capacity Model interpretation of why standard detox protocols fail in SIBO, MCAS, and long COVID, and what the upstream lesion actually requires.
#mycotoxins#mitochondria#colonocyte-bioenergetics - Host Capacity Model· May 14, 2026· 14 min· Mechanistic inference
Beyond Weight Loss: How GLP-1 Agonists Influence Gut Bioenergetics and the Host Capacity Model
Emerging research suggests GLP-1 receptor agonists do more than regulate glucose and appetite. They also influence colonocyte mitochondrial function, the gut oxygen gradient, the microbiome, and barrier integrity, with direct relevance to the Host Capacity Model.
#glp-1#semaglutide#colonocyte-bioenergetics
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