9 articles
- Host Capacity Model· June 11, 2026· 28 min· Mechanistic inference
Why Dysbiosis, SIBO, Hydrogen Sulfide Intolerance, MCAS, and Long COVID May All Be Downstream of a Single Event
Dysbiosis, SIBO, hydrogen sulfide intolerance, MCAS, and long COVID may all be downstream of one event: the colonocyte losing control of oxygen, butyrate, and its own mitochondria. The Host Capacity Model in full.
#host-capacity-model#colonocyte#butyrate - Mitochondria· May 25, 2026· 5 min· Mechanistic inference
Ulcerative Colitis Starts in the Mitochondrion
For forty years the field treated UC as immune dysregulation. The 2024 and 2025 literature finally admits what was upstream all along.
#ulcerative-colitis#ibd#mitochondria - Mitochondria· April 25, 2026· 6 min· Mechanistic inference
The Iron-Sulfur Cluster Crisis: Why Your Mitochondria Can't Recover (And Why Practitioners Don't Talk About It)
Your SIBO keeps coming back. Your IBS flares without warning. Your energy tanked despite "fixing" your microbiome. Most practitioners will blame the bacteria, the metabolites
#mitochondri#dysbiosis#colonocyte - Case Reasoning· April 20, 2026· 4 min· HCM interpretation
What I've Learned About Long COVID: A Gut-First Framework
I've spent the last few months diving deep into the long COVID literature, and something keeps jumping out at me: we've been looking at this disease from the wrong angle. Most discussions start with t
#butyrate#colonocyte#barrier - Mitochondria· April 20, 2026· 10 min· HCM interpretation
Why Butyrate Supplementation Makes Chronic Gut Dysfunction Worse: The Data They Don't Show You
ou ve probably heard it.
#mitochondri#butyrate#colonocyte - Host Capacity Model· April 18, 2026· 34 min· HCM interpretation
Why It's Impossible to Treat Chronic Gut Dysfunction at the Bacterial Level
What the data across genetics, mitochondrial testing, immune markers, bile acid chemistry, stool sequencing, and motility assessment actually shows in every chronic gut case I see
#butyrate#bile#colonocyte - SIBO· April 15, 2026· 4 min· Mechanistic inference
Why Some People Never Recover From Gut Disorders: The Overlooked Genetic Architecture Driving Butyrate Failure, Dysbiosis, and Chronic Symptoms
Most people still talk about SIBO, IBS, hydrogen sulfide overgrowth, or post-infectious gut dysfunction as if the microbiome alone is the entire story.
#sibo#mitochondri#butyrate - SIBO· April 14, 2026· 15 min· Mechanistic inference
When the Virus Leaves But the Lock Stays: Post-Viral Epigenetic Silencing in Gut Dysfunction and…
When the Virus Leaves But the Lock Stays: Post-Viral Epigenetic Silencing in Gut Dysfunction and the Pharmacological Case for HDAC Inhibition A mechanistic investigation for clinicians — educational purposes only. Not a clinical framework. Not a prescription endorsement. The Parad
#sibo#dysbiosis#colonocyte - Mitochondria· April 6, 2026· 11 min· Mechanistic inference
When Your Gut Locks Its Own Front Door — Methylation, Epigenetics, and Why Chronic Gut Dysfunction…
When Your Gut Locks Its Own Front Door — Methylation, Epigenetics, and Why Chronic Gut Dysfunction Resists Recovery **Part 1 of 3: The Epigenetic Lock on Butyrate Transport** — — - In my last post, I explored how SIRT3 — a mitochondrial enzyme most people have never heard of — go
#mitochondri#butyrate#colonocyte
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