- SIBO·May 25, 2026· 16 min·Mechanistic inferenceEducational only
Why Does SIBO Keep Coming Back After Treatment?
Recurrent SIBO is the equilibrium state of an unaddressed host substrate failure. Antimicrobials reduce overgrowth without restoring the colonocyte bioenergetic capacity that defines which microbes can dominate. A Host Capacity Model reading of the recurrence cycle, the SLC5A8 / Fe-S / CD38-NAD+-SIRT3 mechanisms behind it, and what an HCM-anchored approach actually looks like.
#sibo#recurrent-sibo#host-capacity-model#dysbiosis#h2s-sibo#methane-sibo#rifaximin#case-reasoning#mechanism#colonocyte-bioenergetics#nad#sirt3#cd38#slc5a8Read mechanism → - Host Capacity Model·May 14, 2026· 32 min·Mechanistic inferenceEducational only
Why Your Chronic Illness Got Dramatically Worse in Perimenopause: The Hormonal Cascade Driving Gut, Mast Cell, Brain Fog, and Fatigue Symptoms in Your 40s
What the research now shows about why women in their 40s experience the emergence or sudden worsening of MCAS, histamine intolerance, SIBO, autoimmune flares, and post viral illness, and where the actual upstream lesion lives.
#perimenopause#mcas#histamine#hpa-axis#mitochondria#estrobolome#host-capacity#hrt#case-reasoningRead mechanism → - Host Capacity Model·May 14, 2026· 30 min·Mechanistic inferenceEducational only
Why Your Brain Fog Won't Lift: The Six Mechanisms of Cognitive Dysfunction in Chronic Illness, and Why Standard Interventions Keep Failing
What patients with persistent brain fog across long COVID, MCAS, SIBO, perimenopause, and ME/CFS have in common, and where the actual lesion lives.
#brain-fog#long-covid#mcas#mitochondria#methylation#host-capacity#case-reasoningRead mechanism → - Host Capacity Model·May 14, 2026· 28 min·Mechanistic inferenceEducational only
Why hEDS, POTS, and MCAS Almost Always Come Together: The Mechanistic Triad and the Upstream Lesion Standard Medicine Doesn't Treat
Why hEDS, POTS, and MCAS cluster as one integrated illness — three faces of a structural vulnerability decompensating against a shared bioenergetic capacity ceiling.
#heds#pots#mcas#host-capacity#mitochondria#connective-tissue#case-reasoningRead mechanism → - Host Capacity Model·May 14, 2026· 32 min·Mechanistic inferenceEducational only
Why Long COVID Won't Resolve: A Mechanistic Reading of Viral Persistence, Mitochondrial Dysfunction, and the Gut–Brain Axis the Standard Model Is Missing
What three years of research actually shows about viral persistence, serotonin depletion, mitochondrial impairment, microclots, and EBV reactivation — and the single upstream layer that ties them together.
#long-covid#mitochondria#viral-persistence#mcas#gut-brain#host-capacity#case-reasoningRead mechanism → - Host Capacity Model·May 14, 2026· 25 min·Mechanistic inferenceEducational only
Why Your Stool Test Doesn't Match Your Symptoms: The Mechanistic Limits of GI-MAP, BiomeFx, and Comprehensive Stool Analysis
What GI-MAP, BiomeFx, Genova, and comprehensive stool panels actually measure, what they cannot, and how to read your own gut when the report falls short.
#stool-testing#gi-map#biomefx#dysbiosis#host-capacity#case-reasoning#siboRead mechanism → - Host Capacity Model·May 14, 2026· 22 min·Mechanistic inferenceEducational only
Why Every Protocol Stops Working After Two Weeks: The Mechanistic Pattern Hiding in Plain Sight in Chronic SIBO, MCAS, and Long COVID
The pattern nobody has named — and what it's actually telling you about your upstream lesion. Why pharmacologically unrelated protocols all plateau on the same two-to-three-week curve, and what that convergence reveals about where your lesion actually lives.
#host-capacity#sibo#mcas#long-covid#protocol-failure#case-reasoningRead mechanism →
Receive new articles.
New mechanistic essays delivered when published. Compatible with the existing Substack readership at @mohammedattallah.