The limits are published alongside the reasoning.
- Evidence tiers
Every article carries an explicit evidence tier, so established biology is never presented as if it were clinical proof.
Read the claim ledger - What this does not prove
Mechanistic pieces are required to state their own limits and the competing explanations that would fit the same data.
See the counterarguments - Published corrections
Where the reasoning has been revised, the revision is recorded rather than quietly edited away.
Review the standards
Pick the sentence that sounds like your situation.
- Why does my SIBO keep coming back?
- Are SIBO breath tests actually reliable?
- Why don't antihistamines settle my symptoms?
- Can I have mast cell activation with normal tryptase?
- Why won't my Long COVID symptoms resolve?
- Why did COVID trigger this in me and not others?
- Why are my labs normal when I feel terrible?
- Why doesn't my stool test match my symptoms?
- Why does every protocol stop working after two weeks?
- Why did butyrate or probiotics make me worse?
- What do bile acids have to do with my gut symptoms?
- Can gut health affect my hormones and egg quality?
Educational mechanistic writing. It does not diagnose, and it does not replace the clinician treating you.
Seven mechanistic threads run through this library.
Recurrent SIBO & breath-test interpretation
14 articles · recurrent SIBO
Mast-cell activation, tryptase & histamine
19 articles · mast cell activation
Long COVID, post-viral gut–immune & POTS
13 articles · Long COVID gut symptoms
Colonocyte bioenergetics, butyrate & oxygen
19 articles · colonocyte bioenergetics
Bile acids, TUDCA & C. difficile ecology
5 articles · bile acid dysfunction
Gut–hormone axis, fertility & estrobolome
3 articles · gut microbiome and fertility
Lab-pattern interpretation
6 articles · lab pattern interpretation
8 articles
- Case Reasoning· August 26, 2026· 18 min· Clinical pattern observation
Long COVID, MCAS, Mold, Heavy Metals, SIBO and Mitochondrial Collapse: A Case That Shows What Happens When We Treat the Target but Forget the Host
A complex case combining Long COVID, ME/CFS physiology, hyperadrenergic POTS, MCAS-type hyperreactivity, recurrent SIBO and methanogen overgrowth, mycotoxin findings, elevated toxic metals and profound mitochondrial respiratory-chain impairment — read as a single host-capacity failure rather than a list of separate targets.
#long-covid#me-cfs#hyperadrenergic-pots - SIBO· May 25, 2026· 16 min· Mechanistic inference
Why Does SIBO Keep Coming Back After Treatment?
Recurrent SIBO may represent an equilibrium state of an unaddressed host substrate failure. Antimicrobials reduce overgrowth without restoring the colonocyte bioenergetic capacity that defines which microbes can dominate. A Host Capacity Model reading of the recurrence cycle, the SLC5A8 / Fe-S / CD38-NAD+-SIRT3 mechanisms behind it, and what an HCM-anchored approach actually looks like.
#sibo#recurrent-sibo#host-capacity-model - Host Capacity Model· May 14, 2026· 32 min· Mechanistic inference
Why Your Chronic Illness Got Dramatically Worse in Perimenopause: The Hormonal Cascade Driving Gut, Mast Cell, Brain Fog, and Fatigue Symptoms in Your 40s
What the research now shows about why women in their 40s experience the emergence or sudden worsening of MCAS, histamine intolerance, SIBO, autoimmune flares, and post viral illness, and where the actual upstream lesion lives.
#perimenopause#mcas#histamine - Host Capacity Model· May 14, 2026· 30 min· Mechanistic inference
Why Your Brain Fog Won't Lift: The Six Mechanisms of Cognitive Dysfunction in Chronic Illness, and Why Standard Interventions Keep Failing
What patients with persistent brain fog across long COVID, MCAS, SIBO, perimenopause, and ME/CFS have in common, and where the actual lesion lives.
#brain-fog#long-covid#mcas - Host Capacity Model· May 14, 2026· 28 min· Mechanistic inference
Why hEDS, POTS, and MCAS Almost Always Come Together: The Mechanistic Triad and the Upstream Lesion Standard Medicine Doesn't Treat
Why hEDS, POTS, and MCAS cluster as one integrated illness — three faces of a structural vulnerability decompensating against a shared bioenergetic capacity ceiling.
#heds#pots#mcas - Host Capacity Model· May 14, 2026· 32 min· Mechanistic inference
Why Long COVID May Not Resolve: A Mechanistic Reading of Viral Persistence, Mitochondrial Dysfunction, and the Gut–Brain Axis the Standard Model Is Missing
What three years of research actually shows about viral persistence, serotonin depletion, mitochondrial impairment, microclots, and EBV reactivation — and a candidate upstream layer that may tie them together.
#long-covid#mitochondria#viral-persistence - Host Capacity Model· May 14, 2026· 25 min· Mechanistic inference
Why Your Stool Test Doesn't Match Your Symptoms: The Mechanistic Limits of GI-MAP, BiomeFx, and Comprehensive Stool Analysis
What GI-MAP, BiomeFx, Genova, and comprehensive stool panels actually measure, what they cannot, and how to read your own gut when the report falls short.
#stool-testing#gi-map#biomefx - Host Capacity Model· May 14, 2026· 22 min· Mechanistic inference
Why Every Protocol Stops Working After Two Weeks: The Mechanistic Pattern Hiding in Plain Sight in Chronic SIBO, MCAS, and Long COVID
The pattern nobody has named — and what it's actually telling you about your upstream lesion. Why pharmacologically unrelated protocols all plateau on the same two-to-three-week curve, and what that convergence reveals about where your lesion actually lives.
#host-capacity#sibo#mcas
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