10 articles
- MCAS & Mast Cells· July 17, 2026· 28 min· Mechanistic inference
Rethinking Chronic Dysbiosis, Mast Cell Activation, and the Failure of Intestinal Ecological Control
Why the microbiome may remain unstable until the intestinal epithelium regains the capacity to metabolize microbial products, consume oxygen, regulate inflammation, and rebuild itself
#dysbiosis#mast-cells#mcas - Host Capacity Model· June 11, 2026· 28 min· Mechanistic inference
Why Dysbiosis, SIBO, Hydrogen Sulfide Intolerance, MCAS, and Long COVID May All Be Downstream of a Single Event
Dysbiosis, SIBO, hydrogen sulfide intolerance, MCAS, and long COVID may all be downstream of one event: the colonocyte losing control of oxygen, butyrate, and its own mitochondria. The Host Capacity Model in full.
#host-capacity-model#colonocyte#butyrate - Frameworks· May 29, 2026· 21 min· HCM interpretation
What May Be Driving IBD? A Mechanistic Reading of Crohn's Disease and Ulcerative Colitis
IBD is not a single autoimmune disease. At the cellular level both Crohn's and ulcerative colitis are dominated by colonocyte bioenergetic failure — loss of butyrate oxidation, collapse of the gut oxygen gradient, and the inflammatory cascade that follows. A mechanistic reading anchored in primary research from Roediger 1990 onward, and why standard immunosuppression contains the response but does not restore the upstream lesion.
#ibd#crohns-disease#ulcerative-colitis - Fertility· May 8, 2026· 4 min· Literature-supported mechanism
How Dysbiosis Disrupts Hormonal Health, Ovulation, and Egg Quality From the Inside Out
The fertility conversation has become overwhelmingly hormone-centric, but one of the most important mechanistic layers is still being underappreciated: the inflammatory dialogue between the gut microbiome and the ovary itself.
#butyrate#dysbiosis#lps - Case Reasoning· April 20, 2026· 4 min· HCM interpretation
What I've Learned About Long COVID: A Gut-First Framework
I've spent the last few months diving deep into the long COVID literature, and something keeps jumping out at me: we've been looking at this disease from the wrong angle. Most discussions start with t
#butyrate#colonocyte#barrier - Mitochondria· April 20, 2026· 10 min· HCM interpretation
Why Butyrate Supplementation Makes Chronic Gut Dysfunction Worse: The Data They Don't Show You
ou ve probably heard it.
#mitochondri#butyrate#colonocyte - Host Capacity Model· April 18, 2026· 34 min· HCM interpretation
Why It's Impossible to Treat Chronic Gut Dysfunction at the Bacterial Level
What the data across genetics, mitochondrial testing, immune markers, bile acid chemistry, stool sequencing, and motility assessment actually shows in every chronic gut case I see
#butyrate#bile#colonocyte - SIBO· April 15, 2026· 4 min· Mechanistic inference
Why Some People Never Recover From Gut Disorders: The Overlooked Genetic Architecture Driving Butyrate Failure, Dysbiosis, and Chronic Symptoms
Most people still talk about SIBO, IBS, hydrogen sulfide overgrowth, or post-infectious gut dysfunction as if the microbiome alone is the entire story.
#sibo#mitochondri#butyrate - Mitochondria· April 15, 2026· 6 min· Mechanistic inference
When the Gut Lowers the Seizure Threshold
Metabolites, Microglia, and the Butyrate Mitochondria Axis
#mitochondri#butyrate#bile - Mitochondria· April 6, 2026· 11 min· Mechanistic inference
When Your Gut Locks Its Own Front Door — Methylation, Epigenetics, and Why Chronic Gut Dysfunction…
When Your Gut Locks Its Own Front Door — Methylation, Epigenetics, and Why Chronic Gut Dysfunction Resists Recovery **Part 1 of 3: The Epigenetic Lock on Butyrate Transport** — — - In my last post, I explored how SIRT3 — a mitochondrial enzyme most people have never heard of — go
#mitochondri#butyrate#colonocyte
Receive new articles.
New mechanistic essays delivered when published. Compatible with the existing Substack readership at @mohammedattallah.