The limits are published alongside the reasoning.
- Evidence tiers
Every article carries an explicit evidence tier, so established biology is never presented as if it were clinical proof.
Read the claim ledger - What this does not prove
Mechanistic pieces are required to state their own limits and the competing explanations that would fit the same data.
See the counterarguments - Published corrections
Where the reasoning has been revised, the revision is recorded rather than quietly edited away.
Review the standards
Pick the sentence that sounds like your situation.
- Why does my SIBO keep coming back?
- Are SIBO breath tests actually reliable?
- Why don't antihistamines settle my symptoms?
- Can I have mast cell activation with normal tryptase?
- Why won't my Long COVID symptoms resolve?
- Why did COVID trigger this in me and not others?
- Why are my labs normal when I feel terrible?
- Why doesn't my stool test match my symptoms?
- Why does every protocol stop working after two weeks?
- Why did butyrate or probiotics make me worse?
- What do bile acids have to do with my gut symptoms?
- Can gut health affect my hormones and egg quality?
Educational mechanistic writing. It does not diagnose, and it does not replace the clinician treating you.
Seven mechanistic threads run through this library.
Recurrent SIBO & breath-test interpretation
16 articles · recurrent SIBO
Mast-cell activation, tryptase & histamine
23 articles · mast cell activation
Long COVID, post-viral gut–immune & POTS
18 articles · Long COVID gut symptoms
Colonocyte bioenergetics, butyrate & oxygen
20 articles · colonocyte bioenergetics
Bile acids, TUDCA & C. difficile ecology
7 articles · bile acid dysfunction
Gut–hormone axis, fertility & estrobolome
8 articles · gut microbiome and fertility
Lab-pattern interpretation
6 articles · lab pattern interpretation
23 articles · showing 12
- SIBO· October 25, 2026· 25 min· Mechanistic inference
What If We’re Missing Something About ADHD and Autism? The Biology That Begins Before Birth
Maternal Immune Activation, GABA Signaling, Epigenetics, the Gut Microbiome, and the Early Development of a Brain Built for Survival
#bile-acids#estrogen#progesterone - SIBO· October 24, 2026· 13 min· Mechanistic inference
The Bile Acid–Estrogen Connection: A Missing Piece in Women’s Hormonal and Gut Health
One of the most interesting patterns I’ve been investigating through my work with women experiencing hormonal changes, gastrointestinal dysfunction, and complex chronic illness involves something that often receives very little attention
#histamine#mast-cells#bile-acids - MCAS & Mast Cells· October 23, 2026· 28 min· Mechanistic inference
Why Progesterone Calms One Woman but Sends Another Into Panic: The Hidden Biology of Hormonal Sensitivity
Why women can experience severe anxiety, insomnia, panic, and emotional changes despite normal hormone tests—and what allopregnanolone, GABA receptors, childhood trauma, neuroinflammation
#hormone#gut#progesterone - SIBO· October 22, 2026· 31 min· Mechanistic inference
Facial Flushing, Racing Heart, Gut Pain, and Crashing After Meals: Could Excess Gut Serotonin Be Driving Mast Cell Activation?
The hidden connection between serotonin overload, Prevotella copri, impaired serotonin clearance, and the gut–immune–nervous system.
#mast-cell-activation#gut-health#sertonin - SIBO· October 8, 2026· 33 min· Mechanistic inference
Bile Acids, GLP-1, and the Overlooked Connection Between the Microbiome and Metabolic Health
I get asked about GLP-1 medications quite frequently, particularly semaglutide and tirzepatide, and whether their benefits extend beyond weight loss and blood glucose regulation.
#long-covid#dysautonomia#bile-acids - SIBO· October 7, 2026· 20 min· Mechanistic inference
When the Gut Changes, the Brain Does Not Read the Diagnosis: What One Pediatric Autism/ADHD Case Taught Me About Phenols, Mucosal Immunity, FMT, Streptococcus, and Metabolic State
I have been working through a pediatric case that has made me think deeply about the way we approach children with autism, ADHD, childhood apraxia of speech, PANS-like symptoms, gastrointestinal dysfunction, histamine intolerance, unusual
#gut#autism#adhd - SIBO· September 30, 2026· 29 min· Mechanistic inference
10 Things I Have Learned About Long COVID From Client Data and Research
I have not written in depth about Long COVID for a while, although it has continued to appear repeatedly in the complex cases I analyze.
#long-covid#sibo#pots - Host Capacity Model· September 27, 2026· 29 min· Mechanistic inference
FKBP5, Cortisol, Childhood Environment, Epigenetic Programming, and the Developmental Biology Behind ADHD and Other Neuropsychiatric Phenotypes
One of the areas I have been working on is trying to understand what happens when genetics, childhood environment, stress physiology, and neurodevelopment are no longer treated as separate subjects.
#ocd#adhd#bile-acids - SIBO· September 14, 2026· 19 min· Mechanistic inference
ME/CFS, Butyrate, and Host Capacity: What a Severe Case Reveals About the Microbiome–Host Relationship
I have been studying the gastrointestinal physiology of ME/CFS for some time, but a severe long-duration case I am currently analyzing has pushed me to think much more carefully about what we actually mean when we say that the microbiome
#sibo#histamine#mast-cells - SIBO· September 3, 2026· 17 min· Mechanistic inference
Mold Toxicity Is More Than Exposure: The Mitochondria–Gut–Immune Cascade Behind Chronic Illness
From my research into mold, mycotoxins, mitochondrial physiology, gut ecology, immune signaling and host genetics, and from the patterns I continue to examine while working through complex gastrointestinal, autonomic, neurological
#microbime#mast-cell-activation#mold - MCAS & Mast Cells· August 31, 2026· 20 min· Mechanistic inference
The Post-COVID Ciprofloxacin Injury Neuroimmune Trap: Bladder Dysfunction, Small-Fiber Neuropathy, MRGPRX2 Mast Cells, HLA Genetics, Mitochondria and the Gut-Brain Axis
I recently had a discovery call with a complex post-COVID client whose case made me look much more deeply at how the bladder, peripheral nervous system, autonomic nervous system, mast cells, mitochondria, vascular system, immune tolerance
#mcas#ciprofloxacin#hla - Host Capacity Model· August 5, 2026· 6 min· Mechanistic inference
Why Dysbiosis Keeps Coming Back: The Overlooked Vitamin B2–Butyrate–Oxygen Connection
Riboflavin sits in the electron-transfer chemistry that lets colonocytes burn butyrate and hold the colon hypoxic. A mechanistic account of why dysbiosis recurs when that oxygen-consuming step is limited.
#riboflavin#vitamin-b2#butyrate
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