The limits are published alongside the reasoning.
- Evidence tiers
Every article carries an explicit evidence tier, so established biology is never presented as if it were clinical proof.
Read the claim ledger - What this does not prove
Mechanistic pieces are required to state their own limits and the competing explanations that would fit the same data.
See the counterarguments - Published corrections
Where the reasoning has been revised, the revision is recorded rather than quietly edited away.
Review the standards
Pick the sentence that sounds like your situation.
- Why does my SIBO keep coming back?
- Are SIBO breath tests actually reliable?
- Why don't antihistamines settle my symptoms?
- Can I have mast cell activation with normal tryptase?
- Why won't my Long COVID symptoms resolve?
- Why did COVID trigger this in me and not others?
- Why are my labs normal when I feel terrible?
- Why doesn't my stool test match my symptoms?
- Why does every protocol stop working after two weeks?
- Why did butyrate or probiotics make me worse?
- What do bile acids have to do with my gut symptoms?
- Can gut health affect my hormones and egg quality?
Educational mechanistic writing. It does not diagnose, and it does not replace the clinician treating you.
Seven mechanistic threads run through this library.
Recurrent SIBO & breath-test interpretation
14 articles · recurrent SIBO
Mast-cell activation, tryptase & histamine
19 articles · mast cell activation
Long COVID, post-viral gut–immune & POTS
13 articles · Long COVID gut symptoms
Colonocyte bioenergetics, butyrate & oxygen
19 articles · colonocyte bioenergetics
Bile acids, TUDCA & C. difficile ecology
5 articles · bile acid dysfunction
Gut–hormone axis, fertility & estrobolome
3 articles · gut microbiome and fertility
Lab-pattern interpretation
6 articles · lab pattern interpretation
8 articles
- Fertility· May 8, 2026· 4 min· Literature-supported mechanism
How Dysbiosis Disrupts Hormonal Health, Ovulation, and Egg Quality From the Inside Out
The fertility conversation has become overwhelmingly hormone-centric, but one of the most important mechanistic layers is still being underappreciated: the inflammatory dialogue between the gut microbiome and the ovary itself.
#butyrate#dysbiosis#lps - Case Reasoning· April 27, 2026· 21 min· Clinical pattern observation
The Same Barrier Collapses Everywhere: Why Dysbiosis Causes ADHD, Brain Fog, Anxiety, Depression, and Chronic Fatigue Simultaneously—And Why You Can't Treat Them Separately The Discovery That Changes
I ve spent months in the primary literature exploring a phenomenon that mainstream medicine completely misses: the same physical structures that seal your gut are the identical structures that seal your brain, and dysbiosis doesn t break just one of them it breaks both simultaneo
#dysbiosis#barrier - MCAS & Mast Cells· April 24, 2026· 22 min· Mechanistic inference
MTHFR Is Not Your Problem: The Complete Methylation Architecture Science Has Never Fully Told You
Let me be direct with you: the way MTHFR is discussed online and even in most clinical settings is wrong in a way that is making people sicker.
#mitochondri#barrier - Case Reasoning· April 20, 2026· 4 min· HCM interpretation
What I've Learned About Long COVID: A Gut-First Framework
I've spent the last few months diving deep into the long COVID literature, and something keeps jumping out at me: we've been looking at this disease from the wrong angle. Most discussions start with t
#butyrate#colonocyte#barrier - Mitochondria· April 20, 2026· 10 min· HCM interpretation
Why Butyrate Supplementation Makes Chronic Gut Dysfunction Worse: The Data They Don't Show You
ou ve probably heard it.
#mitochondri#butyrate#colonocyte - Fertility· April 19, 2026· 15 min· Mechanistic inference
Microplastics and Forever Chemicals: Why Your Body Can't Detox Them — and What It Actually Needs
The biology behind the Netflix panic and why generic "detox" protocols keep failing the people who need them most.
#barrier#fertility - Mitochondria· April 15, 2026· 6 min· Mechanistic inference
When the Gut Lowers the Seizure Threshold
Metabolites, Microglia, and the Butyrate Mitochondria Axis
#mitochondri#butyrate#bile - Frameworks· April 7, 2026· 5 min· HCM interpretation
Toxic Bile Acids: When Your Own Detergent Becomes a Weapon Against You
Bile acids are detergents. When their composition shifts toward the more hydrophobic secondary forms, the same molecules that emulsify fat can injure the epithelium they pass over.
#bile-acids#deoxycholic-acid#lithocholic-acid
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