Long COVID and post-infectious syndromes
For illness that began with an infection and did not end with it, where the honest position is several competing hypotheses rather than one story.
This page is for people whose illness has a start date and an infection attached to it — COVID, another virus, a gut infection, or an unnamed febrile illness — and who have since accumulated autonomic, cognitive, immune and digestive symptoms that no single specialist owns. Post-infectious illness is an area where confident single-cause narratives are common and poorly supported. This analysis keeps the competing hypotheses visible and says which parts of your record favour which.
What records in this area tend to contain
These are descriptions of records, not diagnostic criteria. Recognising several of them does not mean you have a condition, and none of them is being asserted about you.
- A datable infection followed by incomplete recovery over months or years
- Post-exertional symptom worsening with a delayed onset
- Autonomic features, cognitive slowing, and unrefreshing sleep together
- New or worsened GI symptoms and food reactivity dating from the illness
- Immune findings — reactivations, autoantibodies, inflammatory markers — of contested significance
- Normal routine bloods alongside substantial functional loss
The analytical work on a case like this
- The full post-infectious chronology, including partial recoveries and relapse triggers
- Autonomic, immune, endothelial, metabolic, barrier and microbiome domains read together
- Which of the major published hypotheses your record supports, weakly supports, or contradicts
- Reactivation, persistence, autoimmunity and dysregulation candidates, each graded
- Contribution of the gut–immune interface, where the record permits it
- What has been ruled out properly, and what has only been assumed
What the work is trying to answer
These are the questions the reconstruction is built around. They are questions, not promises — some records answer them clearly and some do not, and the written synthesis says which.
- Which competing explanation does this specific record favour, and by how much?
- Are there treatable contributors that the post-viral label has absorbed?
- Which findings are consistent with more than one hypothesis and therefore cannot discriminate?
- What is the single most informative next question for your clinicians?
What would argue against the leading reading
Every synthesis states the alternatives it could not exclude. For this area, the most important ones are:
- Viral persistence, immune dysregulation, autoimmunity, endothelial injury, and microbiome shift — none currently settled
- Autonomic dysfunction as the proximate cause of most of the functional loss
- Deconditioning and sleep disruption compounding an initial insult
- A separate condition that began coincidentally during the illness period
- Untreated common contributors — iron, thyroid, sleep apnoea, depression — folded into the label
BiomeLogic does not diagnose Long COVID, ME/CFS, or any post-infectious condition, does not treat them, and does not offer antiviral, immunomodulatory, or other therapeutic direction. This is educational mechanistic analysis prepared for discussion with your medical team.
Mohammed Attallah is the founder of BiomeLogic and developed the Host Capacity Model independently; it is a working framework, not medical consensus or a clinically validated instrument. He is not a licensed clinician. Every output is educational analysis prepared for review, modification, or rejection by your own medical team. Full scope statement →
The service is chosen by scope, not by condition
There is no separate price for any pattern on this page. Gate 1 is free, takes a few minutes, needs no files, and ends with a written reply about whether the analysis suits your case and which engagement would fit.
Comprehensive Systems-Biology Case Analysis
$995The whole case: full-record reconstruction, a live working session, and a written synthesis with an intervention discussion framework.
Read the full scope →Complex Case Deep Dive
$1,500Unusually extensive or internally contradictory records needing expanded chronology and cross-test reconciliation. Scope, not a better method.
Read the full scope →
Related reading on this site
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hEDS, hypermobility and autonomic–GI overlap
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