Hypothesis
SIBO, MCAS, and long COVID may share an upstream host-capacity substrate in some complex overlapping cases.
Evidence summary
Pattern-level synthesis across published mechanistic work on epithelial bioenergetics, mast cell biology, and post-viral mitochondrial dysfunction.
Representative citations
Limitations
No prospective study tests this shared-substrate framing directly.
Competing explanation
These conditions may share comorbidity for unrelated reasons (genetic predisposition, common triggers, ascertainment bias).
What would weaken this claim
Cohort data showing that the three conditions cluster only by chance after adjustment for shared risk factors.
Related pages
Educational mechanistic analysis only. Not medical diagnosis or treatment.