Histamine Intolerance: Why the DAO Enzyme Story Is Incomplete, and the Real Reason Your Low Histamine Diet Stopped Working — The Place You Are In

You have read everything you can find about histamine intolerance. You know what foods contain histamine. You can recite the DAO enzyme story in your sleep. You have tried the low histamine diet, possibly more than once. You have probably tried DAO supplements. You have tried quercetin, vitamin C, copper, B6, and the standard cofactor stack. You have tried H1 and H2 blockers, alone and in combination. You have tried mast cell stabilizers including cromolyn, ketotifen, and quercetin. You have eliminated the obvious triggers and many of the non obvious ones. The pattern of your experience is recognizable. The first two weeks of any new intervention were the best. Your skin calmed. Your gut quieted. Your head stopped feeling pressurized after meals. Your sleep deepened. You felt the relief you had been searching for. Then by week three or four, the relief plateaued. By month two, you were either back to a slightly improved baseline or you had developed a new sensitivity that was not there before. You started reacting to things that had never bothered you. Foods on the safe list became unsafe. Supplements that had been the foundation of your protocol stopped working. The list of triggers expanded faster than you could eliminate them. You found yourself eating fifteen foods, then twelve, then eight, and your life had narrowed to fit the diet rather than the diet supporting your life