What I've Learned About Long COVID: A Gut-First Framework — 6. Genetic Vulnerability: Your SNPs Stack the Deck

Not everyone gets long COVID at the same severity. This is where your genomics matter. Certain SNPs&#8212;variants in MTHFR, COMT, CYP gene families, and others&#8212;affect how efficiently you methylate, detoxify, and regulate inflammation. If you inherited variants that reduce methylation capacity or slow detoxification, you&#8217;re starting from a metabolic disadvantage when COVID hits. The virus exploits this vulnerability.