How Dysbiosis Disrupts Hormonal Health, Ovulation, and Egg Quality From the Inside Out — section

The mechanistic problem begins in the gut. Dysbiosis characterized by depletion of beneficial organisms such as Lactobacillus , Bifidobacterium , and butyrate-producing taxa like Faecalibacterium prausnitzii shifts the intestinal ecosystem toward expansion of Gram-negative organisms capable of producing high levels of lipopolysaccharide (LPS). Simultaneously, intestinal barrier integrity deteriorates through loss of tight junction proteins including occludin and ZO-1. This creates increased intestinal permeability and allows LPS to translocate into systemic circulation, producing chronic low-grade metabolic endotoxemia.