Why Butyrate Supplementation Makes Chronic Gut Dysfunction Worse: The Data They Don't Show You — What I’m Not Saying

I&#8217;m not saying butyrate is evil. I&#8217;m not saying you should never have butyrate in your system. Physiologic amounts of butyrate, produced from fiber fermentation in a system with adequate colonocyte capacity, are beneficial. What I&#8217;m saying is this: If your colonocytes can&#8217;t oxidize butyrate efficiently, supplementation is contraindicated. The mechanism explains why you feel worse. The data I&#8217;ve gathered from clients shows this pattern repeatedly. And the lack of oxidation capacity measurement in clinical practice represents a critical gap in how we assess and treat these conditions.