The Epigenetic Truth About Why Your Mast Cells Won’t Calm Down (And How to Actually Fix It) — section

Mast cells are immune cells that live in your tissues &#8212; not just in your gut, but throughout your body: your skin, lungs, nasal passages, brain lining, and connective tissue. They&#8217;re essentially first responders. When they detect something threatening &#8212; a pathogen, a toxin, a physical injury &#8212; they release a burst of chemical mediators stored in internal granules. Histamine is the most well-known, but they also release tryptase, prostaglandins, leukotrienes, and dozens of cytokines.