Why Some People Never Recover From Gut Disorders: The Overlooked Genetic Architecture Driving Butyrate Failure, Dysbiosis, and Chronic Symptoms — TLR4 — Endotoxin Sensor

SNP: rs4986790 (G allele, Asp299Gly) Effect: Heightened sensitivity to LPS Risk: Small increases in endotoxin &#8594; disproportionately large cytokine response Downstream: Mitochondria shut down oxidative metabolism for days to weeks.