The Hidden Cost of Antihistamines: How Blocking Histamine Silences Your Most Important Neural Network — section

In the brain: ACh is critical for memory formation, learning, attention, and executive function. It drives the encoding of new memories in the hippocampus and maintains cognitive sharpness through cortical activation. This is why Alzheimer&#8217;s disease &#8212; the quintessential disease of memory loss &#8212; is fundamentally a disease of cholinergic neuron death.