The Same Barrier Collapses Everywhere: Why Dysbiosis Causes ADHD, Brain Fog, Anxiety, Depression, and Chronic Fatigue Simultaneously—And Why You Can't Treat Them Separately The Discovery That Changes — Conclusion: The Unified Cascade

Your gut barrier and your blood-brain barrier are built from the same proteins. Your dysbiotic microbiota break both simultaneously. The SCFA deficiency drives barrier failure, microglial dysmaturation, and the collapse of every neurotransmitter system. The result is not one disease. It&#8217;s five expressions of the same disease: ADHD (immature circuits + neurotransmitter depletion) Brain fog (energy depletion + chronic microglial activation) Anxiety (GABA insufficiency + HPA dysregulation) Depression (dopamine suppression + BDNF loss + energy depletion) Chronic fatigue (acetyl-CoA starvation + mitochondrial suppression) These appear together because they share a common root. They respond to the same treatment&#8212;SCFA restoration&#8212;because the mechanism is unified at the molecular level. The clinical evidence supports this completely. The only barrier to implementation is paradigm inertia&#8212;the reluctance of medicine to abandon the brain-centric, neurotransmitter-focused model and embrace the reality that the microbiota-barrier-brain axis is the fundamental system through which all five of these conditions arise and through which they can be resolved. This is the future of psychiatric and neurological medicine. And the science is already here. This synthesis represents months of mechanistic exploration of the dysbiosis-barrier-microglial-neuro dysfunction axis acro