Why Some People Never Recover From Gut Disorders: The Overlooked Genetic Architecture Driving Butyrate Failure, Dysbiosis, and Chronic Symptoms — SLC5A8 (SMCT1)

Example SNP: rs3019595 (T allele) Effect: Reduced transporter expression Risk: Lower butyrate absorption &#8594; impaired &#946;-oxidation &#8594; increased epithelial oxygenation Clinical implication: Even with adequate SCFAs, the gut remains metabolically &#8220;under-fueled.&#8221;