The Single Molecule Driving Both Your SIBO and Your MCAS (And Why Nothing Has Worked) — Why nothing you’ve tried has worked the way it was supposed to

Now look at what you&#8217;ve been doing. A mast cell stabilizer blocks mast cell degranulation downstream of SUCNR1 activation. It does nothing to lower succinate. The mast cells are still being told to expand and prime themselves. You are managing the explosion, not removing the fuse. A round of rifaximin kills overgrown bacteria. It does nothing to restore colonocyte mitochondrial function, restore epithelial hypoxia, or reverse the TET-locked epigenetic silencing in the cells that determine which microbes can survive. The bacteria you killed will be replaced &#8212; by the same kind of bacteria &#8212; within weeks, because the host environment hasn&#8217;t changed. A probiotic adds organisms to a niche that has lost the ability to host them. They don&#8217;t colonize. They pass through. You feel maybe slightly different for a few days. A low-FODMAP diet starves the bacteria producing the symptomatic gases. Symptoms quiet. Then the diet narrows your microbial diversity further, the colonocytes get even less butyrate (because the fiber-fermenting bacteria are gone), and host capacity drops further. The diet works while you&#8217;re on it, and the underlying lesion gets worse the longer you stay on it. Antihistamines, vitamin C megadoses, quercetin, NAC &#8212; these are downstream interventions on a system whose upstream fuel source has not been addressed. Some of them genui