Why Some People Never Recover From Gut Disorders: The Overlooked Genetic Architecture Driving Butyrate Failure, Dysbiosis, and Chronic Symptoms — A New Framework: Precision Gut Medicine Guided by Genomics

For the first time, we are moving beyond generic SIBO protocols toward a model that incorporates: transporter function mitochondrial oxidation capacity cytokine response amplitude epithelial hypoxia resilience motility regulation barrier gene integrity detox genetics for hydrogen sulfide and ROS This is not theoretical. This framework already helps explain: why some clients react to probiotics why antimicrobials work once for some people and never again for others why hydrogen sulfide becomes pathological only in certain genotypes why some patients relapse after every viral or food poisoning event why restoring butyrate oxidation is the real therapeutic pivot point The microbial patterns are predictable only when the host is understood.