How Dysbiosis Disrupts Hormonal Health, Ovulation, and Egg Quality From the Inside Out — section

This creates a dual failure state. First, inflammatory signaling suppresses local estrogen production within the follicle through aromatase inhibition. Second, SCFA depletion reduces endometrial responsiveness to estrogen through altered receptor expression and epigenetic dysregulation. In other words, dysbiosis can simultaneously impair estrogen synthesis and blunt estrogen signaling.