Why Your Chronic Illness Got Dramatically Worse in Perimenopause: The Hormonal Cascade Driving Gut, Mast Cell, Brain Fog, and Fatigue Symptoms in Your 40s — How I Work With This

Biomelogic is an independent systems biology consulting practice that reads complex cases at the integrative bioenergetic and hormonal layer that the standard treatment model does not address. Perimenopausal chronic illness flare is one of the most common reasons women in their forties reach out, often integrated with one or more of the conditions I have written about elsewhere: long COVID, MCAS, SIBO, the hEDS POTS MCAS triad, histamine intolerance, ME/CFS, autoimmune disease, and persistent brain fog. The work I do is mechanistic case analysis. I integrate your full longitudinal history, your laboratory data, your cycle and hormonal history, your symptom configuration across the five mechanisms, your prior intervention history including HRT trials and your response to them, and the host capacity framework into a defensible model of what configuration your case sits in, where the dominant intervention points are, what to communicate to your medical team about HRT decisions and chronic illness management, and how to sequence the work over the timescale your biology actually operates on. I do not prescribe, diagnose, or replace your medical team. I do the integrative analytic work that the standard appointment does not have time for, and I deliver it in a form your existing clinicians (your gynecologist, your menopause specialist, your immunologist, your gastroenterologist, your