Why Some People Never Recover From Gut Disorders: The Overlooked Genetic Architecture Driving Butyrate Failure, Dysbiosis, and Chronic Symptoms — SLC16A1 (MCT1)

Example SNP: rs1049434 (A allele) Effect: Decreased monocarboxylate influx efficiency Risk: Colonocytes cannot use butyrate &#8594; glycolytic shift &#8594; oxygen leak into lumen Why it matters: Higher oxygen favors Enterobacterales, Klebsiella, and H&#8322;S producers.