The Single Molecule Driving Both Your SIBO and Your MCAS (And Why Nothing Has Worked) — What this reframes

You are not psychosomatic. You are not &#8220;sensitive.&#8221; You are not having &#8220;an autonomic response to stress.&#8221; Your gut is not &#8220;in your head.&#8221; Your nervous system is not the problem &#8212; though it is being driven crazy by the signal coming up from your gut. You have a specific, identifiable, mechanistic failure in a specific cell type, producing a specific signaling molecule, that drives every cluster of symptoms you have. The failure has a name: loss of host capacity at the colonocyte level . The mediator has a name: succinate . The downstream pathways have names: SUCNR1, TET inhibition, &#945;-ketoglutarate depletion, lineage skew, barrier collapse. This is not vague. It is not &#8220;functional.&#8221; It is biology. The papers are published. The mechanism is in Nature . The cell type has been imaged. The molecule has been measured in the serum of patients with Crohn&#8217;s, with IBS, with fibromyalgia. The receptors have been mapped. The therapeutic implications follow from the mechanism &#8212; and they are not what conventional medicine is currently doing for you. The reason you have IBS and MCAS and dysbiosis is because all three are manifestations of one process. They get diagnosed separately because medicine is organized into specialties &#8212; gastroenterology over here, allergy/immunology over there, infectious disease somewhere el