What Actually Causes POTS? A Mechanistic Reading of Postural Orthostatic Tachycardia Syndrome — thesis

POTS is not one disease. Four mechanistically distinct pathways — post-viral autonomic ganglion dysfunction, gut-driven vagal dysregulation, connective-tissue-mediated venous pooling, and primary deconditioning — produce the same phenotype. Each needs different intervention. A Host Capacity Model stratification of why standard POTS treatment helps some patients and not others, and how to tell which pathway is dominant in a given case.