Beyond Weight Loss: How GLP-1 Agonists Influence Gut Bioenergetics and the Host Capacity Model — Conclusion: A New Frontier in Gut Bioenergetics

The expanding literature on GLP-1 agonists suggests they are more than metabolic drugs. They are signaling molecules with effects on cellular energy metabolism, mitochondrial function, and the gut ecosystem. For patients with chronic patterns where colonocyte bioenergetic compromise appears to be a relevant upstream node, the systemic and local effects of GLP-1 signaling are worth understanding in collaboration with the licensed medical team responsible for prescribing decisions. The framing offered by the Host Capacity Model emphasizes restoring the conditions inside the host that allow normal physiology to reassert itself. GLP-1 signaling is one of several inputs that may interact with that restoration.