Why Some People Never Recover From Gut Disorders: The Overlooked Genetic Architecture Driving Butyrate Failure, Dysbiosis, and Chronic Symptoms — The Central Failure Point: Butyrate Oxidation Collapse

Butyrate oxidation is not just &#8220;fuel for colonocytes.&#8221; It is the metabolic switch that keeps: epithelial mitochondria functioning oxygen levels low in the gut lumen anaerobes stable pathogens suppressed inflammation tightly regulated When butyrate oxidation fails, the gut shifts into a completely different ecological and immunological state. This is the common denominator I keep finding across IBD, IBS, SIBO, hydrogen sulfide overgrowth, post-infection syndromes &#8212; and even certain colon cancer pathways. And genetics determines how easily this switch fails.