MTHFR Is Not Your Problem: The Complete Methylation Architecture Science Has Never Fully Told You — section

MTHFR is a rate-limiting enzyme. It is not a master regulator, a disease gene, or a diagnosis. It is one pinch point in a 47-step biochemical architecture that operates across your cytoplasm, mitochondria, and nucleus simultaneously. Polymorphisms in that enzyme reduce throughput &#8212; but throughput reduction is not failure. And treating reduced throughput with methylfolate supplementation, without understanding the thermodynamic state of the entire system, is pharmacological guesswork.