Why Some People Never Recover From Gut Disorders: The Overlooked Genetic Architecture Driving Butyrate Failure, Dysbiosis, and Chronic Symptoms — HIF1A — Hypoxia Response Factor

SNP: rs11549465 (T allele) Effect: Altered hypoxia-adaptive transcription Risk: Epithelium fails to maintain low-oxygen environment &#8594; butyrate consumers decline.