The Single Molecule Driving Both Your SIBO and Your MCAS (And Why Nothing Has Worked) — The standard story is wrong

Walk into any conventional clinic with a typical chronic-gut presentation and here&#8217;s what you&#8217;ll be told: You have IBS &#8212; that&#8217;s a &#8220;functional disorder,&#8221; meaning we don&#8217;t know why your gut hurts but we can rule out the scary stuff. Take a low-FODMAP diet and an antispasmodic. You have MCAS &#8212; your mast cells are &#8220;overactive.&#8221; Take an H1 blocker, an H2 blocker, a mast cell stabilizer, and try not to react to too many things. You probably have SIBO or dysbiosis &#8212; your microbes are off. Take rifaximin, then a probiotic, then a herbal antimicrobial, then maybe FMT if you can afford it. Three specialists. Three diagnoses. Three protocols. You execute every one of them, sometimes for years. The symptoms shuffle. Maybe one calms while another flares. Maybe everything quiets for a few weeks and then comes roaring back. You start a food list. The food list grows. Your social life shrinks. Your nervous system frays. And underneath it all, the question no one will answer: if these are three unrelated diseases, why do they always show up together in the same patients? They don&#8217;t show up together by accident. They show up together because they are not three diseases. They are three downstream consequences of one upstream failure. And there is a single molecule sitting at the center of all of them. That molecule is succina