Histamine Intolerance: Why the DAO Enzyme Story Is Incomplete, and the Real Reason Your Low Histamine Diet Stopped Working — How I Work With This

Biomelogic is an independent systems biology consulting practice that reads complex cases at the bioenergetic and integrative layer that the standard treatment model does not address. Histamine intolerance is one of the most common reasons patients reach out, alongside chronic SIBO, MCAS, long COVID, the hEDS POTS MCAS triad, and the broader category of host capacity limited illness. The work I do is mechanistic case analysis. I integrate your full longitudinal history, your laboratory data, your symptom pattern across the four sources and two breakdown pathways, your prior intervention history, and the bioenergetic capacity framework I have described in this essay into a defensible model of what configuration your case sits in, where the dominant intervention points are, and what to communicate to your medical team about each component. I do not prescribe, diagnose, or replace your medical team. I do the integrative analytic work that the standard appointment does not have time for, and I deliver it in a form your existing clinicians can review, discuss, and act on. The patients I work with are typically two to five years into chronic histamine intolerance, have tried multiple single source interventions, have reached the point where more of the same is not going to resolve the illness, and need a mechanistic reading of their case to design a coherent path forward. The standar