Why Some People Never Recover From Gut Disorders: The Overlooked Genetic Architecture Driving Butyrate Failure, Dysbiosis, and Chronic Symptoms — IL-1β — Master Pro-Inflammatory Cytokine

SNP: rs16944 (A allele) Effect: Upregulated IL-1&#946; transcription Risk: Chronic epithelial inflammation &#8594; impaired SCFA utilization &#8594; dysbiosis locked in place.