The Sigma-1 Receptor, Allopregnanolone & Mast Cell Activation – A Thread Worth Following — section

Sig-1R is a chaperone protein sitting at the ER-mitochondria interface. It regulates calcium handling, mitochondrial bioenergetics, and – critically – mast cell activation. When Sig-1R is underexpressed or dysfunctional, you lose a key brake on inflammatory signaling. Mast cells become more reactive. ER stress compounds. The gut-brain axis destabilizes.