The Sigma-1 Receptor, Allopregnanolone & Mast Cell Activation – A Thread Worth Following — section

Allopregnanolone is a neurosteroid made from progesterone – it requires functional 5-alpha reductase (yes, genetics matter here, SRD5A2 variants included) and adequate progesterone substrate. It’s the brain’s endogenous GABA-A positive allosteric modulator. Calm. Anti-inflammatory. Neuroprotective.