Why Butyrate Supplementation Makes Chronic Gut Dysfunction Worse: The Data They Don't Show You — What Actually Happens When Colonocytes Can’t Oxidize Butyrate

This is where the paradox emerges. When colonocytes are bioenergetically compromised&#8212;starved of micronutrients, flooded with inflammatory signals, compromised by dysbiosis-derived LPS, or operating under hypoxic stress&#8212;they lose the capacity to efficiently oxidize butyrate. Butyrate accumulates. It doesn&#8217;t get burned for energy. It sits in the cell. And when it accumulates? HDAC inhibition becomes pathological.