What I Found in My Clients' Tests After Long COVID — And Why It Changes Everything — What All the Tests Are Saying in One Sentence

Post-COVID is not a mystery. It is a predictable systems failure that runs in a specific sequence: Viral insult &#8594; LPS translocation &#8594; TLR4 activation &#8594; chronic NF-&#954;B signaling &#8594; CD38 upregulation &#8594; NAD&#8314; depletion &#8594; SIRT1/SIRT3 failure &#8594; mitochondrial collapse &#8594; colonocyte energy failure &#8594; deeper barrier breakdown &#8594; more LPS &#8594; the loop continues. At the same time: IFN-&#947; &#8594; IDO1 activation &#8594; tryptophan hijacked &#8594; serotonin and melatonin depleted &#8594; quinolinic acid accumulates &#8594; neuroinflammation &#8594; brain fog, mood collapse, sleep disruption, SSRI resistance. The bacteria are not the enemy. The gut is not the enemy. The system has been reprogrammed into a self-sustaining failure state &#8212; and standard medicine is looking at the outputs, not the engine.