The Sigma-1 Receptor, Allopregnanolone & Mast Cell Activation – A Thread Worth Following — thesis

Most people in this space know the tryptophan trap. Serotonin gets hijacked. IDO flips on. Quinolinic acid builds up. Neuroinflammation follows. But there’s a parallel story that doesn’t get nearly enough attention – and it runs straight through the sigma-1 receptor (Sig-1R). Her