Why Butyrate Supplementation Makes Chronic Gut Dysfunction Worse: The Data They Don't Show You — The Bottom Line

The assumption that &#8220;more butyrate is better&#8221; is breaking. In patients with colonocyte dysfunction and dysbiosis, it&#8217;s backwards. If you&#8217;ve felt worse on butyrate supplements, you now understand why. Your system couldn&#8217;t oxidize it. The accumulation drove HDAC inhibition pathology. Your mast cells activated. Your epithelium destabilized. Your brain fogged. You weren&#8217;t defective. The recommendation was. The path forward doesn&#8217;t involve adding more butyrate. It involves understanding why your colonocytes can&#8217;t process what&#8217;s already being produced&#8212;and addressing that upstream problem. That&#8217;s the work. Have you experienced worsening symptoms on butyrate supplementation? Does this framework resonate with your experience? Drop a comment&#8212;I&#8217;m tracking patterns. This article is educational and exploratory. It is not medical advice. If you&#8217;re currently supplementing with butyrate and experiencing symptom changes, work with a qualified practitioner before making changes. Mohammed's Substack is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.