{"version":"v1","state":{"id":"sulfide-overload","title":"Sulfide-overload state","summary":"Expansion of sulfate-reducing organisms raises luminal H₂S beyond the colonocyte's mitochondrial sulfide-oxidising capacity.","characteristicMechanisms":["Inhibition of SCAD and complex IV by H₂S","Reduced SQOR throughput"],"ecologicalConsequences":["Stalled β-oxidation","Plausible mast-cell sensitisation via TRPA1"],"relatedConcepts":["colonocyte-bioenergetics","mcas-histamine-patterns"],"relatedChains":["h2s-shared-driver-chain"],"relatedArticles":["the-single-molecule-driving-both-your-sibo-and-your-mcas-and"],"relatedClaims":["h2s-inhibits-colonocyte-beta-oxidation","h2s-as-shared-driver-of-sibo-and-mcas"],"spatialFocus":["colonocyte","mitochondria"],"temporalPhases":["chronic"],"lastReviewed":"2026-05-11"}}