{"version":"v1","state":{"id":"oxygen-leak","title":"Mucosal oxygen leak state","summary":"Loss of physiological epithelial hypoxia raises mucosal O₂, allowing facultative anaerobes to expand and obligate anaerobes to contract.","characteristicMechanisms":["Falling PPAR-γ tone","Stabilisation of HIF-1α dysregulated","Nitrate respiration available"],"ecologicalConsequences":["Enterobacteriaceae expansion","Loss of SCFA producers","Self-reinforcing inflammation"],"relatedConcepts":["oxygen-gradient-failure","nitrate-respiration","dysbiosis-ecology"],"relatedChains":["oxygen-leak-cascade"],"relatedArticles":[],"relatedClaims":["epithelial-hypoxia-suppresses-facultative-anaerobes","nitrate-respiration-feeds-pathobionts"],"spatialFocus":["mucus layer","epithelial layer","lumen"],"temporalPhases":["compensatory","chronic"],"lastReviewed":"2026-05-11"}}