{"version":"v1","state":{"id":"mast-cell-amplification","title":"Mast-cell amplification state","summary":"Mucosal mast cells become hyper-responsive, lowering activation thresholds and amplifying gut–brain symptoms.","characteristicMechanisms":["Tryptase / histamine / PGD2 release","MRGPRX2 sensitisation","Sensory afferent priming"],"ecologicalConsequences":["Increased epithelial permeability","Visceral hypersensitivity"],"relatedConcepts":["mcas-histamine-patterns"],"relatedChains":["h2s-shared-driver-chain"],"relatedArticles":["the-epigenetic-truth-about-why-your-mast-cells-won-t-calm-do"],"relatedClaims":["mast-cell-activation-amplifies-barrier-and-vagal-signaling"],"spatialFocus":["mucosal mast cells","lamina propria","enteric nervous system"],"temporalPhases":["acute","chronic","compensatory"],"lastReviewed":"2026-05-11"}}