{"version":"v1","state":{"id":"inflammatory-dominance","title":"Inflammatory dominance state","summary":"TLR4/NF-κB tone is elevated, mast cells primed, and the mucosal cytokine milieu shifts toward TNF-α / IL-1β / IL-6.","characteristicMechanisms":["TLR4 activation by LPS","NF-κB amplification","Mast-cell sensitisation"],"ecologicalConsequences":["Nitrate substrate for Enterobacteriaceae","Barrier permeability worsens"],"relatedConcepts":["gut-barrier-dysfunction","mcas-histamine-patterns"],"relatedChains":["lps-aromatase-paradox"],"relatedArticles":[],"relatedClaims":["lps-translocation-via-tlr4-drives-low-grade-endotoxemia","mast-cell-activation-amplifies-barrier-and-vagal-signaling"],"spatialFocus":["lamina propria","mucosal mast cells","submucosa"],"temporalPhases":["acute","chronic"],"lastReviewed":"2026-05-11"}}