{"version":"v1","state":{"id":"epithelial-energy-failure","title":"Epithelial energy failure state","summary":"Colonocyte mitochondrial throughput drops below the rate needed to oxidise available SCFA and consume luminal O₂.","characteristicMechanisms":["Reduced β-oxidation","Lower epithelial O₂ consumption","NAD⁺ depletion / SIRT3 dysfunction"],"ecologicalConsequences":["Mucosal hyperoxia","Loss of obligate-anaerobe advantage"],"relatedConcepts":["colonocyte-bioenergetics","butyrate-oxidation","mitochondrial-dysfunction"],"relatedChains":["oxygen-leak-cascade","h2s-shared-driver-chain"],"relatedArticles":["why-some-people-never-recover-from-gut-disorders-the-overloo"],"relatedClaims":["colonocyte-energy-failure-drives-oxygen-leak","colonocyte-beta-oxidation-of-butyrate"],"spatialFocus":["colonocyte","mitochondria","epithelial layer"],"temporalPhases":["chronic","collapse"],"lastReviewed":"2026-05-11"}}