{"version":"v1","chain":{"id":"primary-ovarian-aging-chain","title":"(Competing) Primary ovarian aging / mtDNA damage explains poor egg quality","question":"Could ovarian aging alone explain the same fertility patterns without invoking the gut?","summary":"Conventional view: oocyte mitochondrial DNA damage and follicle-pool depletion drive declining egg quality independently of any gut-derived inflammation.","steps":[{"nodeId":"concept:mitochondrial-dysfunction","rationale":"Accumulated oocyte mtDNA damage with age impairs spindle integrity.","evidence":"established"},{"nodeId":"article:10-critical-points-about-maternal-mitochondrial-dysfunction-","rationale":"Mitochondrial inheritance and quality govern oocyte competence.","evidence":"established"}],"competingChains":["lps-aromatase-paradox"],"relatedConcepts":["mitochondrial-dysfunction"],"relatedArticles":["10-critical-points-about-maternal-mitochondrial-dysfunction-"],"evidenceFloor":"established","lastReviewed":"2026-05-11"}}